Bücher veröffentlicht von Mdpi AG

Coal is an important natural resource. Improving the safety levels of the coal mining process while ensuring that coal production is at an acceptable level are problems to which we must attribute great importance. This reprint focuses on the safety of coal mine production, including the latest work from leading researchers. It discusses and studies the progress of research on safety in theory, experiments and simulation. The content covers the safety of coal mine-related fields, including mine ventilation, fire and explosion prevention, gas drainage, coal dust prevention, safety equipment, and other aspects of safety technology research. Despite the interdisciplinary nature of the different studies, the common theme of security is closely linked to the different studies in this period.

This reprint presents recent advances in understanding the molecular processes that take place in adipose tissue inflammation in the context of obesity. It discusses the impact of adipose tissue inflammation on systemic metabolic alterations associated with excess adiposity, as well as its repercussion in several pathological conditions that may help to understand obesity-associated metabolic derangements.

The aim of this Special Issue is to describe the recent approaches for and efficacious treatment of wounds from different aspects. These include the description of new ingredients (e.g. A.P.I., polymers) able to stimulate the wound healing, new delivery systems, new formulations as well as new understanding in the stimulation of physiological biochemical pathways (that change according to many factors such as age, sex, etc.) involved in wound healing.

This reprint delves deep into the principles, practices, and possibilities of the sustainable circular bioeconomy. Within these pages, you will find a wealth of knowledge and insights contributed by experts, researchers, and practitioners who have dedicated their lives to advancing the boundaries of sustainability. Each chapter of this reprint is carefully crafted to provide a holistic view of the subject, covering a wide range of topics, including renewable energy, waste management, food-energy-water nexus, digital innovation in sustainability, aquaculture, agriculture, biotechnology, and more.

This IJERPH special issue on "Health Care from the Patient's Perspective" focuses on the perspective of patients as experts, on their challenges and experiences with health care, embedded in a biopsychosocial framework. In doing so, the special issue offers contributions across the entire health and disease continuum from health promotion to rehabilitation and to the outpatient setting described from different perspectives on disease-related situations such as Parkinson's disease, stroke, or multiple sclerosis, diabetes mellitus, and others, to methodological highlights, with a focus on qualitative, but also participatory research as well as quantitative approaches. Experiential research forms the core of this issue. They will not only provide insights into complex health care situations and ethical issues, but also highlight patient-centered problems as a possible starting point for health system and/or policy improvement. It will also take an interprofessional perspective on patients' care providers, family members, or caregivers. We received 19 impressive and important contributions to healthcare that we encourage you to read.

The incidence and prevalence of Alzheimer's Disease are increasing worldwide due to aging and comorbidities. The classical neuropathogenetic model, which concentrates on brain amyloid plaque deposition, neurofibrillary tangles, and cholinergic system dysfunction, is being expanded and integrated with newer molecular models. Understanding the relationships between the classical pathogenetic pathways and newer hypotheses is imperative for guiding future research and developing effective drugs. The existence of newer molecular mechanisms such as risk factors, comorbidities like vascular diseases and diabetes mellitus, and neuroanatomical/neurofunctional alterations as blood-brain barrier breakdown and neurovascular unit dysfunction, offer potential targets to improve Alzheimer's Disease diagnosis and treatment. This reprint provides an overview of the pathophysiologic role of newer and older molecular mechanisms of Alzheimer's Disease, shedding light on new insights for the development of new therapeutic approaches. It also highlights newer candidate markers of disease onset and progression.

10th Anniversary of Plants-Recent Advances and Perspectives is a scientific paper collection specially published on the anniversary of Plants. Covering all major areas of plant science, it is a valuable guide through current achievements and future discoveries in this scientific field.

Both vegetables and fruits, as plant-based foods, are known for their abundance of bioactive compounds, which play a crucial role in disease prevention. Researchers from various disciplines have dedicated significant efforts to understanding the compositions of these bioactive compounds and exploring how fruits and vegetables contribute to promoting health and preventing diseases. This reprint presents studies on the composition of bioactive compounds found in the main fruit and vegetable species, their health effects when consumed fresh or processed, and their mechanisms of action against human diseases, including in vitro and in vivo models.

It has been known that cellular glutathione content and its speciation play a role, among others, in redox homeostasis, cell cycle control, immunological defense, and pathological abnormalities. Furthermore, it plays a significant role in the biotransformation of drugs and other endogenous or exogenous electrophilic species. Most of these cellular functions are related to the thiol function of the cysteine moiety.This reprint presents the publications that appeared in the Special Issue of Molecules, "Glutathione: Chemistry and Biochemistry." The first three contributions review the present-day knowledge of the GSH/GSSG system and the most important GSH-related proteins involved in regulating various cellular events. The subsequent four contributions present selected interventions that modulate the GSSG/2GSH system. One of the contributions to this session describes a new HPLC method to quantify the reduced and oxidized glutathione levels. The third session involves three contributions demonstrating the role of GSH in the metabolism of different candidate and clinically used anticancer drugs. One of the contributions, a theoretical work, provides helpful information for developing GSH analogs with high ACE inhibitor activity.By purpose and content, this Special Issue is addressed to the vast number of life science researchers (academic and industrial) and medical professionals who are interested in or already engaged in research that involves glutathione.

This reprint contains 10 papers published in a Special Issue of the MDPI journal Mathematics concerned with hypercompositional algebra. The contributions, written by 24 authors from 10 different countries, cover a wide range of topics concerning the theoretical aspects, applications, and computational issues of algebraic hyperstructures. The reader will find a wide range of problems, arguments and methods that illustrate and provide insight into the variegated features of this theory. This reprint will be of interest to those working in abstract algebra, hypergroup theory, finite geometries or combinatorics, as well as to those who wish to familiarise themselves with recent advances in hypercompositional algebra.

In the last 20 years, two factors have revolutionized the way space missions and applications are conceived, namely an increased access to space guaranteed by new launch providers and advances in miniaturized technologies. These two factors have rapidly made small satellites a reliable tool for scientific, commercial, and educational activities in space. Acting as a part of a larger mission along with larger satellites, or even substituting the latter in some cases, small satellites have now become a reality in modern space missions. This Special Issue aims to address the recent advances in small satellites' technology and the resulting impact on space missions.

In total, ten papers are included in this reprint. New advances in optoelectronic materials have been reported for crystals, electrodes, and bonding materials. Zakrzewski et al. analyzed photothermal piezoelectric spectroscopy of Cd1¿xBexTe, showing potential in X-ray and ¿-ray detectors. Han et al. investigated characteristics of a copper foil three-electrode planar spark gap high-voltage switch integrated with EFI. Ding et al. showed a way to improve electrochemical migration resistance of nanosilver paste as a bonding material. New advances have been reported for LEDs and photonic crystal waveguides. Bai et al. proposed a new method for the measurement of adhesive force between a single ¿LED and the substrate. Zhang et al. analyzed strain relaxation effect on the peak wavelength of blue micro-LEDs. Shi et al. proposed an all-dielectric terahertz photonic crystal waveguide operating in 6G terahertz communication window. New applications of optoelectronic materials and devices have also been reported for piezoelectric sensors, crystal materials, SAR, and OCT. Wang et al. established a collision model of wheat grains impacting a force plate with a piezoelectric sensor. He et al. demonstrated application of a BaGa4Se7 crystal in a tunable and compact mid-infrared optical parametric oscillator with a repetition rate of up to 250 Hz. Wang et al. proposed a new feature learning method for the automatic target recognition of SAR images. Shi et al. reviewed the quantitative assessment methods used for early enamel caries with OCT.

The challenges in identifying effective therapies for CNS tumors continue to be daunting. Potentially effective targeted therapies must be able to penetrate the blood-brain barrier to reach the tumor and, in sufficient concentrations, to result in meaningful treatment responses. Moreover, molecular targets must be key drivers in the growth and progression of CNS tumors. Numerous potentially efficacious therapies have failed in randomized clinical trials due to other factors, including subclonal genetic intratumoral heterogeneity (particularly within malignant gliomas), epigenetic heterogeneity, and failure to target important factors involved in the tumor microenvironment. Developing effective targeted therapies requires a thorough fundamental understanding of the genetic and epigenetic factors driving tumor progression, the interactions between CNS tumor cells and the tumor microenvironment, and the key mechanisms of tumor treatment resistance.In this Special Issue, experts in the field of CNS tumors will highlight the most promising molecular targets in the development of treatments for patients with CNS tumors.

Mycotoxins contamination is a continuing global problem that severely affects animal health and performance, and further threatens food safety. The industry's common aspiration is to eliminate feed mycotoxins contamination and control their hazards. In recent years, animal mycotoxicosis has occurred frequently all over the world, which has brought huge economic losses to the agriculture industry. The potential damage caused by mycotoxins-induced decreased disease resistance in animals and food safety problems in human health is incalculable. There is a long way to go to prevent mycotoxins hazards. Biodegradation is a promising strategy to eliminate mycotoxins as it can transform mycotoxins into nontoxic or less toxic metabolites under mild conditions, retaining the sensory quality and nutritional value of agricultural commodities. Moreover, animals have a certain ability to detoxify mycotoxins, and some bioactive substances, such as lipoic acid, sporoderm-broken spores of Ganoderma lucidum, and quercetin, can improve the detoxification ability of animals to reduce the toxic effects of mycotoxins. This reprint aimed to gather contributions of original research or reviews related to novel strategies for biodegradation and detoxification of mycotoxins. Topics of interest will include novel mycotoxin-degrading microorganisms and enzymes, fermentation technology to reduce the mycotoxin content in cereal products, studies on alleviating the mycotoxicosis of livestock by the addition of bioactive substances or mycotoxin biodegradation agents, and any preliminary research that promotes progress in this field.

Research performed on robotic applications has significantly expanded in the last decade, and currently, robotic systems are being utilized for many purposes. To achieve this generalized application of robots, researchers have endeavoured to study a wide variety of methods and algorithms in order to properly employ robotic systems in many real-life scenarios. At present, many types of robotic platforms are being employed in various applications, e.g., dual-arm robots, parallel robots, mobile robots, humanoid robots, aerial robots, underwater robots, and micro/nano robots. Moreover, some theoretical tools are specially being used to obtain correct robot performance, e.g., machine learning, artificial intelligence, multi-agent systems, and control and planning theory. The purpose of this reprint is to exhibit the current state of robotic applications. In particular, in addition to introducing novel theories and methods, this reprint is particularly focused on the application of robotic systems in real-life situations. Thus, the presentation of experimental results makes evident the feasibility and usefulness of robotic systems in practical cases. Obviously, this reprint does not intend to exhaustively demonstrate all the current existing robotic applications but rather give an overview of them, revealing the high level of activity in this area. This reprint contains an Editorial, together with 30 contributions in total from countries all around the world, addressing a broad range of robotic applications.