Bücher veröffentlicht von Qizer ul Hassan

Today, its well established that genotoxic chemicals are widely distributed in drugs,pesticides, cosmetics, narcotics, air and water pollutants, food additives and foodcontaminants (Belpomme, 2007; Irigaray, 2007). Intake of DNA damagingenvironmental contaminants can lead to heritable genetic defects, cardiovascularproblems, diabetes, cancer, premature ageing, teratogenic effects andneurodegenerative diseases (Hoeijmakers, 2009; De Flora and Ramel, 1988; Fergusonand Philpott, 2008). Hence, there is a need to develop a suitable strategy to safeguardhuman genetic material from the catastrophic consequences of exposure toenvironmental toxicants.

Scaffold proteins assemble vanous signaling molecules into a signalosome and activate signal transduction cascade. These proteins thus provide platforms for receptors, kinases, phosphatases and other effectors into a functional modules (Good et al., 2011). Scaffold proteins are thus key components ofsignaling networks. Among various domain structures in scaffolding proteins, one commonly found is WD40 repeat. Proteins harboring this domain often act as signaling scaffold in which the WD40 repeat domain form a beta propeller structure for assembling signaling molecules.