Bücher veröffentlicht von Springer Basel

This volume contains solicited articles by speakers at the workshop ranging from expository surveys to original research papers, each of which carefully refereed.

In this book, the discussion of the normal and pathological aspects of anxiety is critically examined. Separate chapters dedicated to each particular type of anxiety such as generalized anxiety disorder, social phobia, posttraumatic stress disorder, panic and obsessive-compulive disorder are included.

The following tract is divided into three parts: Hilbert spaces and their (bounded and unbounded) self-adjoint operators, linear Hamiltonian systemsand their scalar counterparts and their application to orthogonal polynomials.

Particular examples of problems on which substantial progress has been made are the control and stabilization of mechatronic structures, the control of growth of thin films and crystals, the control of Laser and semi-conductor devices, and shape optimization problems for turbomachine blades, shells, smart materials and microdiffractive optics.

This book contains reviews by a renowned group of clinicians and scientists, which consider in great depth the potential involvement of neurogenic inflammation in the pathogenesis of migraine and inhibition of this putative mechanism as a possible mode of action of antimigraine medications. The authors carefully consider current and future potential therapeutic approaches for the abortive as well as preventive treatment of migraine. The pioneering work by Professor Michael A. Moskowitz's group at Harvard gave rise to the "neurogenic hypothesis" of migraine pathogenesis and to an intel­ lectual framework for many aspects of migraine research through a detailed phar­ macological characterization of the trigeminovascular system. This knowledge then spurred detailed research worldwide into the roles of the dural vasculature, trigem­ inal nerve fibers, and sensory neuropeptides, such as substance P and calcitonin gene-related peptide, in migraine. Similar in-depth investigations have not been made of the role of the seventh cranial parasympathetic nerves but this area war­ rants further study because of its potential for interactions with the trigeminovas­ cular system and its clear involvement in cluster headache.

Allelochemicals play a great role in managed and natural ecosystems. The book emphasizes the role of allelochemicals in shaping the structure of plant communities in a broader ecological perspective. (2) Why is it difficult to demonstrate interference by allelochemicals (i.e., allelopathy) in a natural system in its entirety?

Der. vorliegende Band enthält eine Reihe von einführenden Vorlesungen, die von verschiedenen Autoren im Rahmen von zwei DMV-Seminaren zum Thema "Algebraische Transjormationsgruppen und Invariantentheorie" gehalten wur­ den. Entsprechend der allgemeinen Zielsetzung der DMV-Seminare sollten sowohl grundlegende Techniken und Resultate vorgestellt als auch Einblicke in aktuelle Entwickl~ngen gegeben werden. Was die Grundlagen anbetrifft, so haben wir sie hier nicht in vollem Umfang widergegeben. Im Bedarfsfall mag der Leser unsere Bücher "Geometrische Methoden in der Invariantentheorie"l und "Invariant Theory"2 zu Rate ziehen, auf die sich die einführenden Vorträge stützten. Leider konnten auch nicht alle aktuellen Entwicklungen berücksichtigt werden, über die im Seminar berichtet wurde. Die Ziele der hier vorliegenden Beiträge, auf deren Inhalt wir in der Einführung ausführlicher eingehen werden, sind entsprechend unterschiedlicher Natur. Einige liefern Darstellungen bereits publizierter Theorien, wobei sie allerdings ein größeres Gewicht auf Motivation und die Ausführung von Beispie­ len legen, als dies in den Originalarbeiten möglich war. Andere leiten grundle­ gende Resultate auf neue "reise her oder stellen sie aus anderer Sicht dar. Schließlich werden auch noch einzelne Einblicke in aktuelle Forschungsrichtun­ gen gegeben. Wir hoffen, daß durch diesen Band zahlreiche Resultate der Theorie der algebraischen Transformationsgruppen leichter zugänglich geworden sind, und daß der Leser mit ihm eine nützliche Basis für die Lektüre aktueller Forschungsarbeiten erhält.

Angiotensin converting enzyme inhibitors (ACEI) represent the first class of antihypertensive agents that was designed and developed on the basis of a well-defined physiopathological axis of arterial hypertension, a vascular dis­ order that is now becoming one of the major causes of morbidity/mortality, not only in developed societies but also in the highly populated developing coun­ tries [1]. CAPTOPRIL, the prototype of the "PRIL" family, which now comprises more than 40 molecule-species, was quite hazardous and the clinical develop­ ment almost failed when serious side-effects were reported in an alarmist fash­ ion in reputable scientific journals, such as the New England Journal of Medicine and Lancet. Squibb & Sons came very close to withdrawing CAPTOPRIL from clinical investigation [2]. However, after re-examination of the data obtained from different categories of patients and appropriate dose-adjustments, the clinical use of CAPTOPRIL turned out to be revolutionary. The prototype, as well as other members of the "PRIL" family became the starting point for numerous basic and clinical research programs, focusing on the interactions of ACEI with the kinin, endothelin, and nitric oxide systems, and the contribution of the receptors for AT I, AT 2, bradykinin Bland B , ETA and ET B to the pharmacological actions 2 of the respective peptides. This research activity led to the development of new pharmacological agents, such as the angiotensin receptor antagonists and, more recently, the neutral endopeptidase inhibitors. In the near future, bradykinin receptor antagonists also will be available to modulate ACEI phar­ macological actions.

"One should rather go horne and mesh a net than jump into the pond and dive far fishes" (Chinese proverb) Recognizing the precise analytical question and planning the analysis according ly is certainly the first prerequisite for successful trace and ultratrace determina tions.

Twenty five years ago, Bill Stebbins presented the principles of animal psychophysics in an edited volume (Stebbins, 1970) describing an array of modem, creative methodologies for investigating the range of sensory systems in a variety of vertebrate species.

Epidemiological studies of Chronic Bronchitis/ Chronic Obstructive Airway Disease (CB/COAD) have demonstrated that hypersecretory glandular activity, as weIl as infections, are not the most important risk factors determining the serious decline in lung function in this disease.

As part of its scientific activities, the German Research Council on Smoking and Health regularly provides opportunities for scientists to discuss progress in the field of nicotine research.

The German land of Hesse (Bundesland Hessen) is well known for its excellent wines (Rheinhessen), for its financial centre and for its airport (FrankfurtlMain). It is, unjustifiably, far less well known for its importance to thennoregulation. Within the small area of Bad Nauheim, Giessen and Marburg (in alphabetical order) a greater concentration of students of thenno­ regulation has been trained or worked or is working than probably in any other single area of Europe, if not the world. It is thus most appropriate to hold the Ninth International Symposium on the Pharmacology of Thennoregulation in Giessen, from August 7 to 12, 1994. The community of students of thennoregulation was extremely grateful that Professor Kurt Bruck and the lustus-Liebig-University of Giessen had extended this invitation. The same community was even more saddened that Kurt Bruck died on April 27, 1992 and thus could not participate in this event that had been planned to honour his achievements. As a small token of friendship and affection, the many friends of Kurt Bruck from all over the world who will participate in this event dedicate this symposium to the memory of Kurt Bruck. Another staunch friend, researcher of temperature regulation and supporter of this series of symposia died in October 1993: Professor Wilhelm Siegmund Feldberg. We feel fortunate to be able to start this volume with two brief infonnal and personal accounts of professors Bruck and Feldberg.

Antioxidants inhibit the formation and spread of free radicals which can be damaging in biological systems. Free radicals form in biological systems through metabolism, but it is also realized that exogenous environmental sources, such as radiation, food, and drugs, contribute significantly to the generation of free radicals in biological systems.

The international symposium held in October 1984 at the Uni versity of Mannheim was the first with the special aim to expose the connection of the Theory of Delay Eauations and Approximation Theory with the emphasis on constructive methods and applications.

Infection of the lower respiratory tract is a major determinant of the course of cystic fibrosis.

This volume contains the proceedings of a conference held in Wiirzburg, August 20-24, 1990. How trends vary may be seen by comparing these proceedings with previous ones, in particular with the conference held in Dortmund 1986 (proceedings published in ISNM 79).

This book presents different formulations of the equations governing incompressible viscous flows, in the form needed for developing numerical solution procedures.

Jim Douglas, Jr.' These proceedings reflect some of the thoughts expressed at the Oberwolfach Con ference on Porous Media held June 21-27, 1992, organized by Jim Douglas, Jr., Ulrich Hornung, and Cornelius J, van Duijn.

1.1 Background The subject of this book is Morse homology as a combination of relative Morse theory and Conley's continuation principle. 1.1.1 Classical Morse Theory The fact that Morse theory can be formulated in a homological way is by no means a new idea.

A very primitive form of this monograph has existed for about two and a half years in the form of handwritten notes of a course that Alain Y ger gave at the University of Maryland. The objective, all along, has been to present a coherent picture of the almost mysterious role that analytic methods and, in particular, multidimensional residues, have recently played in obtaining effective estimates for problems in commutative algebra [71;5]* Our original interest in the subject rested on the fact that the study of many questions in harmonic analysis, like finding all distribution solutions (or finding out whether there are any) to a system of linear partial differential equa­ tions with constant coefficients (or, more generally, convolution equations) in ]R. n, can be translated into interpolation problems in spaces of entire functions with growth conditions. This idea, which one can trace back to Euler, is the basis of Ehrenpreis's Fundamental Principle for partial differential equations [37;5], [56;5], and has been explicitly stated, for convolution equations, in the work of Berenstein and Taylor [9;5] (we refer to the survey [8;5] for complete references. ) One important point in [9;5] was the use of the Jacobi interpo­ lation formula, but otherwise, the representation of solutions obtained in that paper were not explicit because of the use of a-methods to prove interpolation results.

Herbert Hornlein, Klaus Schittkowski The finite element method (FEM) has been used successfully for many years to simulate and analyse mechanical structural problems. They proceed from the design model as defined for structural analysis, to perform an internal adaption of design pa rameters based on formal mathematical methods.

Der Taschenatlas ist nach Inhalt und Anordnung auf die gegen­ wartig im Gebrauch stehenden Bestimmungsbiicher (A BINZ, Schul- und Exkursionsflora fiir die Schweiz, 19. Auflage von CH. HEm, Basel, Schwabe, 1990, und D. AESCHIMANN et H. M. BUR­ DET, Flore de la Suisse . ¿ Le nouveau Binz. , Neuchiitel, Editions du Griffon, 1989) zugeschnitten und neben und mit diesen beiden Wer­ ken zu beniitzen. Er enthalt sozusagen alle dort behandelten Arten nebst einer groBeren Zahl von Unterarten und Varietaten. FUr die bislang nicht unterschiedenen Kleinarten oder nahestehenden Sippen sowie fiir die Neueinbiirgerungen findet der Leser entspre­ chende Hinweise unter den Anmerkungen zum Bilderteil. Der Taschenatlas tragt, allerdings ohne Anspruch auf unbedingte VollstliiJ. digkeit und ohne allzu scharfe Abgrenzung, die Grenzar­ ten eines die ganze Schweiz umspannenden Giirtels zusammen. Dieser schlieBt folgende Landschaften ein: die franzosischen De­ parte mente Savoyen, Hochsavoyen und Ain, Teile der Departe­ mente Jura, Doubs und Haute-Saone, das Territorium Beifort, das OberelsaB mit den Siidvogesen bis unterhalb der Stadt Colmar, Oberbaden mit Kaiserstuhl, Siidschwarzwald und Hegau, das deutschseitige Bodenseegebiet, Vorarlberg, Liechtenstein, den Vintschgau, in Piemont das Aosta-, das Sesia- und das Eschental, in der Lombardei das Gebiet des Langensees, die Gegend von Varese, das Comerseegebiet, das Veltlin und Teile des Bergamaski­ schen. Die deutsche Ausgabe der Binzschen . Flora. beriicksichtigt ab 13. Auflage ebenfalls die gesamten Grenzgebiete der Schweiz; die Grenzen werden allerdings in Savoyen, im Umkreis des Jura und im Aostatal enger gezogen als im Taschenatlas, wahrend die Bergamasker Alpen (von einzelnen Fundortsangaben ab 18.

The last decades have demonstrated that quantum mechanics is an inexhaustible source of inspiration for contemporary mathematical physics.