Bücher veröffentlicht von Springer International Publishing AG

This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials.

Illustrated in color, this book lays the foundation of practical pathology and provides a scaffold on which to build a knowledge base. Written for the pathologist-in-training, it includes basic introductory material and progresses through each organ system.

This work presents the adaptation of mentalization-based therapy for use in Eating Disorders (MBT-ED). MBT-ED is one of the few therapies for eating disorders that links theory of mind, and attachment and psychodynamic therapies and as such will be of great theoretical interest to a wide variety of clinicians and researchers.

V) An appendix with an LCA report template, a full example LCA report serving as inspiration for students who write their first LCA report, and a more detailed overview of existing LCIA methods and their similarities and differences.

This book presents the theory of integrating implification and it provides a profound evidence based study of Buurtzorg Nederland. The book demonstrates theory building by using the Grounded Theory Methodology as a way to contribute to management theory.

This book is a clear and comprehensive guide that assists readers in translating observations, ideas, and research into articles, reports, or book chapters ready for publication.

Michael Swanson's online discussions with literally thousands of NexStar owners made it clear that there was a desperate need for a book such as this - one that provides a complete, detailed guide to buying, using and maintaining NexStar telescopes.

This new edition to the classic book by ggplot2 creator Hadley Wickham highlights compatibility with knitr and RStudio. ggplot2 is a data visualization package for R that helps users create data graphics, including those that are multi-layered, with ease. With ggplot2, it's easy to: produce handsome, publication-quality plots with automatic legends created from the plot specificationsuperimpose multiple layers (points, lines, maps, tiles, box plots) from different data sources with automatically adjusted common scalesadd customizable smoothers that use powerful modeling capabilities of R, such as loess, linear models, generalized additive models, and robust regressionsave any ggplot2 plot (or part thereof) for later modification or reusecreate custom themes that capture in-house or journal style requirements and that can easily be applied to multiple plotsapproach a graph from a visual perspective, thinking about how eachcomponent of the data is represented on the final plot This book will be useful to everyone who has struggled with displaying data in an informative and attractive way. Some basic knowledge of R is necessary (e.g., importing data into R). ggplot2 is a mini-language specifically tailored for producing graphics, and you'll learn everything you need in the book. After reading this book you'll be able to produce graphics customized precisely for your problems, and you'll find it easy to get graphics out of your head and on to the screen or page.

Through real-world datasets, this book shows the reader how to work with material in biostatistics using the open source software R.

This book highlights the key phases and central findings of Alzheimer¿s Disease research since the introduction of the label ¿Alzheimer¿s Disease¿ in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer¿s drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed?In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer¿s research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer¿s Disease research.The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer¿s Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer¿s research community is finally ready to shed its ¿amyloid-straitjacket¿ that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer¿s Disease research and provide a new and broader perspective on this age-dependent brain disease.

This upper-level open access textbook uses an interdisciplinary perspective to discuss the ¿what and why¿ of public procurement, providing insight into the ¿how¿ of contemporary procurement in the public sector. The authors use theories and exemplary practices to show the next generation of public procurement professionals how public value can be created via the acquisition of works, supplies, or services by organizations operating in the public domain. Perfectly tailored to university students in public administration, law, economics, or management and those in executive education, the book first describes and explains the public procurement process, the concept of public value, the legal context of procurement and how the procurement function is organized in public organizations. The book subsequently explains how a procurement policy can be developed and translated into a procurement strategy, how tenders can be organized, suppliers selected, and contracts designed and evaluated. A final discussion chapter addresses the changes and developments in public procurement and how public procurement is moving forward. The reader of this innovative and accessible book will therefore not only learn what public procurement entails, but also how they can become a professional change agent in the field of public procurement. Forward-thinking and comprehensive, this book offers ideal reading for anyone interested in public procurement.

This book invites snorkelers and divers on an educational visit to the most important ecosystems of the Mediterranean Sea. Keystone species from brown algae to dolphins are presented in their marine habitats and understood as part of a complex ecological system. Instead of grouping animals and plants taxonomically, we have organised them according to the eight main habitats of the Mediterranean Sea. Our journey starts with different types of rocky grounds, then takes you further to the Mediterranean¿s sandy and muddy grounds, and finally ends with the fish and dolphins of the blue open sea.You will be introduced to 220 ecologically significant animal and plant species via the texts of Daniel Abed-Navandi, a long-time lecturer on the biodiversity of the Mediterranean Sea at the University of Vienna, and the photographs of Georg Glaeser, the master behind the camera, who captures marine life on the spot.

In this book, the history of the concepts critical to the discovery and development of aluminum, its alloys and the anodizing process are reviewed to provide a foundation for the challenges, achievements, and understanding of the complex relationship between the aluminum alloy and the reactions that occur during anodic oxidation.

This fully updated textbook provides complete coverage of electrical circuits and introduces students to the field of energy conversion technologies, analysis and design.

This essential metaheuristics tutorial provides descriptions and practical applications in the area of business analytics. It addresses key problems in predictive and prescriptive analysis, while also illustrating how problems that arise in business analytics can be modelled and how metaheuristics can be used to find high-quality solutions.

This book presents the deterministic view of quantum mechanics developed by Nobel Laureate Gerard 't Hooft. Dissatisfied with the uncomfortable gaps in the way conventional quantum mechanics meshes with the classical world, 't Hooft has revived the old hidden variable ideas, but now in a much more systematic way than usual.

In this book, Alison Stone argues that popular music since rock-`n'-roll is a unified form of music which has positive value.

This tenth part of Robert Leeson's collaborative biography of Friedrich August von Hayek explores Hayek's thought on the free market and democracy.

This book assesses the life and success of the writer Paulo Coelho, one of the most fascinating and contemporary writers in the world, through new lenses. This study explores the development of holistic wellness (HWM) and faith development (FDT) throughout the writer's life.

This book provides a fully revised and up-to-date analysis of the Economic and Monetary Union (EMU). By focusing on monetary issues the book offers a better understanding of macroeconomic policies and international policy cooperation, and, by extension, provides a thorough economic assessment of the EMU as an institution as it stands today.

Using the latest research and driven by practical experience from industry, this book gives useful hints to practitioners on how to write and structure requirements. It will benefit those seeking to develop their knowledge of requirements engineering process.

The text describes the main features of currently available heat pumps, focusing on system operation and interactions with external heat sources.

This book outlines how Germans convinced their politicians to pass laws allowing citizens to make their own energy, even when it hurt utility companies to do so. The authors explore how, by taking ownership of energy efficiency at a local level, community groups are key actors in the bottom-up fight against climate change.

This textbook describes the basic mechanical features of concrete and explains the main resistant mechanisms activated in the reinforced concrete structures and foundations when subjected to centred and eccentric axial force, bending moment, shear, torsion and prestressing.

In this book, Warren Keller reveals the secrets of astro-image processing software PixInsight in a practical and easy to follow manner, allowing the reader to produce stunning astrophotographs from even mediocre data.

Clinical Ocular Prosthetics