Bücher veröffentlicht von Springer International Publishing

Samson Abramsky¿s wide-ranging contributions to logical and structural aspects of Computer Science have had a major influence on the field. This book is a rich collection of papers, inspired by and extending Abramsky¿s work. It contains both survey material and new results, organised around six major themes: domains and duality, game semantics, contextuality and quantum computation, comonads and descriptive complexity, categorical and logical semantics, and probabilistic computation. These relate to different stages and aspects of Abramsky¿s work, reflecting its exceptionally broad scope and his ability to illuminate and unify diverse topics.Chapters in the volume include a review of his entire body of work, spanning from philosophical aspects to logic, programming language theory, quantum theory, economics and psychology, and relating it to a theory of unification of sciences using dual adjunctions. The section on game semantics shows how Abramsky¿s work hasled to a powerful new paradigm for the semantics of computation. The work on contextuality and categorical quantum mechanics has been highly influential, and provides the foundation for increasingly widely used methods in quantum computing. The work on comonads and descriptive complexity is building bridges between currently disjoint research areas in computer science, relating Structure to Power.The volume also includes a scientific autobiography, and an overview of the contributions. The outstanding set of contributors to this volume, including both senior and early career academics, serve as testament to Samson Abramsky¿s enduring influence. It will provide an invaluable and unique resource for both students and established researchers.

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.

This book comprises a detailed consideration of novel approaches developed in the field of frequency conversion of laser sources in laser-induced plasmas during the last few years. The aim of the book is to support researchers and other readers in their development in the area of high-order nonlinear spectroscopy. Particularly, the advanced studies of nanoparticles and quantum dots for the formation of new sources of radiation in different short-wavelength spectral ranges show the ways to further implement the specific features of small-sized species in a relatively new field of study-laser ablation induced high-order harmonics generation spectroscopy.Researchers involved in the development of new methods of frequency conversion will benefit from finding the most recent advances in this field. Undergraduate students will discover interesting information about recent findings in plasma harmonic research. Additionally, the usefulness of the book will be demonstrated by the potential applications of the new knowledge developed during recent years for ultrafast pulse generation using the proposed schemes of plasma-light interaction. Thus, the audience may also include those researchers involved in state-of-the-art developments in attophysics. Additionally, any professionals interested in the application of the advanced techniques for material science will also benefit from updating their knowledge of new methods of material studies using high-order nonlinear spectroscopy.

This handbook integrates a range of conceptual and empirical approaches to diplomacy in the context of ongoing technological and societal change. Technological and societal disruptions affect modern diplomacy, altering its character and reforming its way. In light of such changes, this book offers both historical foundations and contemporary perspectives in the field. By doing so, it demonstrates how contemporary change impacts the work of diplomats representing sovereign states. Global diplomatic services will forever be affected by the digitalization of engagement between states during and after the COVID-19 pandemic. In this rapidly changing culture, with burgeoning geopolitical and geostrategic realignment among global powers, the tools of diplomacy have changed. The state¿s foreign policy astuteness and responses to these changes could have long-term impacts. All this culminates in opportunities for improving the management of diplomaticservices and efficiency of the Ministries of Foreign Affairs (MoFA) of various states. This book provides useful insights into how modern diplomacy works, especially the integration of informalities into formal diplomatic practices in complex peace and security environments, within such a framework of change.

It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).CTC play a central role in tumor dissemination and metastasis,and have been established as an important evaluative and research tool in advanced cancer, and potentially important in early stage disease. CTC defines tumor cells circulating in blood, while Disseminated Tumor Cells (DTC) refers to tumor cells identified in bone marrow. CTC/DTC are extremely rare events, even in late stage cancer, and their detection has presented enormous technical challenges, with the emergence of multiple technologies developed to address these challenges, including enrichment, identification and sophisticated analytical techniques to evaluate CTC and other cells in circulation that may also be important in the biology of metastasis.As foundational as CTC/DTC has been, the field of liquid biopsy has expanded well beyond these analytes. The relevance of circulating nucleic acids derived from tumor cells has quickly progressed from research to the clinic. There are now well established clinical applications for using ctDNA/RNA to determine therapeutic targets, follow disease progression and detect cancer recurrence long before routine clinical methods. One of the most exciting new areas of work is the possibility of using these circulating tumor derived nucleic acids to detect cancer at its earliest and potentially most curable stages. Another new and burgeoning area is the detection and analysis of ctExosomes. These highly abundant particles which are actively secreted from tumor (and indeed all) cells represent a novel way to detect and define multiple analytes of importance, including proteins, DNA and meDNA, RNA, miRNA, and other cell components that are protected and preserved in these compact structures.This second edition of Circulating Tumor Cells: Advances in Liquid Biopsy Technologies is entirely new and brings together leaders and innovators in the field of liquid biopsy, including basic and molecular biologists, chemists, engineers, statisticians, experts in tumor banking, test developers, research administrators and clinicians. A special feature of this book is that it includes chapters from the members of the US National Cancer Institute Liquid Biopsy Consortium. This edition also includes many of the participants of the latest international meeting on the Advances in Circulating Tumor Cells (ACTC) which is held in Greece every two years and gathers the most important liquid biopsy investigators from around the world. Thus, this edition represents the most comprehensive and up-to-date resource for those who want to further explore the exciting field of CTC and other liquid biopsy technologies. The new edition will be useful to a wide audience including scientists studying metastasis, cancer researchers, translational scientists, oncologic surgeons, medical oncologists, members of the biopharmaceutical industry, and graduate and undergraduate students studying cancer biology.

The book aims at presenting a multidisciplinary view meant to illustrate several significant efforts and results about the contribution of information technologies to make available new resources and enable rationally usage the existing ones in the context of the ever-growing trends to use ever more resources. Authors from various countries have been invited to contribute so that a rather broad and balanced image about the current trends and recent results obtained could result. The proposed book addresses methodologies and information technology-based tools and systems designed for the efficient use of diverse resources such as manpower and human knowledge, natural resources including water, raw materials and end of life products, financial assets, datasets, and even cultural goods. The book is organized in ten chapters. It is intended to be insightful for researchers, instructors, and planers from various domains. It can also be used as an auxiliary material for postgraduate studies in applied informatics, business administration, industrial engineering, engineering and management, computer, and digital humanities.

This book offers a comprehensive review of crowdfunding at Higher Education Institutions, both in theory and practice. In addition, it sheds new light on the emerging concept of crowdfunding at Higher Education Institutions and presents an overview of current academic discussions and best practices regarding crowdfunding in education.Approaching crowdfunding from an integrated perspective, the book explores the relationship between crowdfunding and higher education institutions from both theoretical and practical perspectives.The theory part outlines why higher institutions should interact with crowdfunding platforms beyond the goal of simply raising funds. It continues to define science crowdfunding and education crowdfunding and provides a literature review of education crowdfunding. It follows with an outline of teaching alternative finance theory.The practice part consists of an attempt to develop a core curriculum for teaching crowdfunding, with casesstemming from university education as well as professional education. Two contributions deal with the implementation of crowdfunding platforms at universities. Furthermore, crowdfunding is then connected to non-fungible tokens used to alleviate student debt. Lastly, crowdfunding is put into the context of crowdsourcing practices.It includes contributions from international academics, scholars and professionals in the field and provides a global, multidimensional perspective on crowdfunding. Lastly, the book is unique in that it points the way forward, both for policymakers and for the research community, in terms of thinking about crowdfunding at Higher Education Institutions and the complex issues surrounding its development.

Rhinoplasty is one of the most challenging procedures in facial plastic surgery, as treatment has to be carefully tailored for each patient; nowadays the concept of preservation rhinoplasty is particularly sought-after, allowing to conserve cartilage bone structure, and avoiding secondary surgery with costal grafts. Thought for the young surgeon in training, this richly illustrated clinical cases atlas in rhinoplasty offers all needed tools to correctly classify the malformation and choose the best reproducible treatment. Chapters clearly illustrate the principal approach with closed technique, to which specific parts on transcolumellar approaches are added, beginning with the simpler cases and progressing stepwise to more complex cases. Each part is supported by the addition of high quality illustrations and surgical videos to foster the reader¿s understanding and preparation of practical steps and best choices, offering direct support in the operating room. The chapters move fromthe clinical examination, to photography, topography and deformation measurement (TDM) in 3D, computer simulations and the building of a dedicated preoperative check list to endure a careful patient approach and secure the best outcomes for the most frequent rhinoplasty cases. Plastic surgeons in training and ENT doctors alike will find this Clinical Atlas of Primary Rhinoplasty to be a handy guide to resort to, when wanting to improve their daily practice.Via app: download the SN More Media app for free, scan a link with play button and videos directly on your smartphone or tablet.

This book presents some of the most advanced leading-edge technology for the fourth Industrial Revolution -- known as ¿Industry 4.0.¿ The book provides a comprehensive understanding of the interconnections of AI, IoT, big data and cloud computing as integral to the technologies that revolutionize the way companies produce and distribute products and the way local governments deliver their services. The book emphasizes that at every phase of the supply chain, manufactures are found to be interweaving AI, robotics, IoT, big data/machine learning, and cloud computing into their production facilities and throughout their distribution networks. Equally important, the authors show how their research can be applied to computer vision, cyber security, database and compiler theory, natural language processing, healthcare, education and agriculture.Presents the fundamentals of AI, IoT, and cloud computing and how they can be incorporatedin Industry 4.0 applicationsMotivates readers to address challenges in the areas of speech communication and signal processingProvides numerous examples, case studies, technical descriptions, and approaches of AI/ML

This book describes Hungarian karst areas and Hungarian karst research results. The chapters present the general characteristics of karst areas, their geology, their paleokarst, their hydrology, their surface and subsurface morphology (more significant caves are classified according to karst areas and their morphology and development is described), ecology and flora and fauna.This book also includes a separate chapter which deals with the history of Hungarian karst and cave research. Another chapter deals with theories that were made during Hungarian karst researches.

This book by leading international experts provides an evidence-based approach to electrical stimulation of the upper airway, beginning with patient selection, implant techniques, trouble shootings, patient pathways, titrations during daytime and sleep as also new innovative techniques such as stimulation of the ansa cervicalis and the phrenic nerve. Key Features: nbsp;      Superbly illustrated schematic drawings and full-colored photographs;nbsp;      Step-by-step description of surgical concepts and techniques on all of the market available systems (Inspire, Nyxoah, LivaNova, Remede);nbsp;      Complete online media library with videos on the surgical procedures;nbsp;      New surgical steps presented for well established procedures (e.g. 2-incicions technique);nbsp;      Discussion of outcomes, success rates, risks, and potential troubleshooting's, where evidenced-based data are not available, expert opinion is provided.  Upper Airway Stimulation in Obstructive Sleep Apnea will be welcomed by residents, fellows, and board-certified surgeons in otorhinolaryngology and head and neck surgery.