Bücher veröffentlicht von Springer International Publishing

Written by twenty-five authors from academia, pharmaceutical industry and Pharmacopeias worldwide, this monograph covers the fundamentals and applications of Quality by Design (QbD) and Analytical Quality by Design (AQbD) in a practical and didactic manner. The book starts by describing the motivation and the urgent need for the implementation of the QbD framework in pharmaceutical development, along with the definition of its major elements: Quality Target Product Profile (QTTP), Critical Quality Attributes (CQAs), Critical Process Parameters (CPPs), Critical Material Attributes (CMAs) and the importance of using multivariate methods of Design of Experiments (DOE). The concept of life cycle and regulatory perspectives are discussed. Three chapters are entirely dedicated to DOE theory from screening to optimization designs. Moreover, a comprehensive discussion on modelling and data treatment is presented. Practical aspects of QbD and DOE for pharmaceutical product and process of different dosage forms is included, as well as a practical guide of the input process variables, material attributes, intermediate, and final quality attributes for the most representative pharmaceutical processes. Analytical Quality by Design (AQbD) is also deeply explored, including risk analysis, definitions of Analytical Target Profile (ATP), Method Operable Design Region (MODR) and the life cycle approach, taking into account the compendial and regulatory perspectives. A detailed example of a new chromatographic method for the quality control of a pharmaceutical topical product based on the AQbD procedure is shown. Finally, advanced statistical approaches and DOE methods for extraction studies of bioactive compounds are also presented. The vast amount of information offered in this book provides a comprehensive perspective on QbD, AQbD and DOE principles, essential tools for modern pharmaceutical and analytical development.

This book offers an authentic and original perspective on the principles of solidarity and rule of law that are variously interconnected and increasingly invoked in international relations and affairs, especially in the context of the European Union, where they are among the founding values common to all Member States.The innovative approach the authors adopt consists in the joint reading of these two principles within the broader framework of EU security, thus offering a new interpretation and fertile ground for further research.Divided into four parts, the authors consider EU security to be linked to the implementation of both these principles, particularly with regard to EU stabilization and enlargement to the Western Balkans, cross-border security, migration and asylum management, criminal justice and human rights, and police and judicial cooperationThe contributions of eminent scholars, international experts,and practitioners are the book¿s greatest strength. In addition, it offers a valuable new perspective on the study of contemporary issues affecting the Western Balkans, but also all Member States and the Union itself. Therefore, the book is an essential resource for students and scholars of EU law, but also for lawyers and professionals involved in criminal proceedings or working in the field of human rights.

This book is published on dedication of Prof. Dr. Igor Sevostianov who passed away in 2021. He was a great Russian-American scientist who made significant contributions in the field of mechanics of heterogeneous media. This book contains research papers from his friends and colleagues in this research field.

This book collects the results presented at the 158th European Study Group with Industry, which took place at the Centre de Recerca Matemàtica in Barcelona in January 2020. The European Study Groups with Industry are a well-recognised forum where mathematicians work with industrial representatives on issues of current interest to companies. At this particular meeting, the problems were chosen to provide a wide variety of subject areas and to appeal to local academics. In this work, the research carried out and the solutions presented to the companies are detailed. In particular, the book focuses on: estimating the difficulty level of mobile games; modelling the stability of human towers; fibre coating in the manufacture of clutch components; safe trajectories of robot arms. The book provides an excellent addition to the canon of Industrial Mathematics. It is addressed to researchers keen to apply mathematics to topical, real-world problems.

This book addresses LGBTQ issues in relation to among others law and policy, mobility and migration, children and family, social well-being and identity, visible and invisible landscapes, teaching and instruction, parades, arts and cartography and mapping. A variety of research methods are used to explore identities, communities, networks and landscapes, all which can be used in subsequent research and classroom instruction and disciplinary and interdisciplinary levels. This extensive book stimulates future pioneering research ventures in rural and urban settings about existing and proposed LGBTQ policies, individual and group mapping, visible and invisible spaces, and the construction of public and private spaces. Through the methodologies and rich bibliographies, this book provides a rich source for future comparative research of scholars working in social work, NGOs and public policy, and community networking and development.

This book covers the topic of history and the role that it played in the Austrio-British philosopher Ludwig Wittgenstein¿s thought. The topic is explored from multiple angles, both chronologically and thematically. Reviewing Wittgenstein¿s two magnum opera - the Tractatus Logico-Philosophicus (1921) and Philosophical Investigations (1952), this work is an investigation into an under-acknowledged element in Wittgenstein¿s thought, one which in many cases acted as an impetus for that life-long process of novel philosophical reflection: History.This volume traces the evolution of Wittgenstein¿s thoughts on time and temporality from the Tractatus, through the Investigations, into some key post-Investigations remarks and also examines the motivations behind Wittgenstein¿s post-Tractarian return to philosophy and, in particular, the unique methodology he developed in order to serve his renewed purpose. The final chapter seeks to answer thequestion, What was Wittgenstein trying to achieve with Philosophical Investigations? This book is of interest to philosophers.

This book addresses current issues surrounding hospital admissions and readmissions and the practice of post-acute and long-term care (LTC). Now in its fully revised and expanded third edition, it contains the most up-to-date knowledge and regulations pertinent to practice in Post-Acute and Long-Term Care Medicine. Post-Acute and Long-Term Medicine is divided into four main sections. The first section is an introduction to long-term care. It includes chapters on home health care, assisted living and residential care, department of veteran affairs and nursing facilities, among others. The second section focuses on clinical medicine in post-acute and long-term care and contains chapters on common clinical conditions, preventing hospital admissions and readmissions, palliative care, weight and nutrition and wound care. The third section details psychosocial aspects of post-acute and long-term care. Chapters in this section describe dementia, delirium, depression, ethical and legal issues and caring for families. The fourth and final section centers on special issues in post-acute and long-term care. This section focuses on documentation and coding, medication management and rehabilitation and maximizing function. The outbreak of COVID-19 has led to two very important new chapters in this section. One chapter discusses challenges and opportunities in post-acute long-term care that have arisen during the pandemic. Another new chapter talks about the importance of virtual care and telemedicine in post-acute and long-term care amidst the COVID-19 outbreak. Written by experts in the field, many of whom have worked within AMDA ¿ The Society for Post-acute and Long-term Care Medicine - to create and disseminate a knowledge base for post-acute and LTC, this is a valuable resource for clinicians and educators seeking to maximize the care and living experience of residents in post-acute and long-term care settings.

This two-part volume examines current pedagogical modules, research directions and other emerging issues in public relations and communication management in Africa. In comparison to its Western and Asian counterparts, the literature on public relations management in Africa is limited, and much of it is examined through the lenses of Western philosophies and pedagogies that do not generally resonate with Africa's socioeconomic, political, and cultural contexts. This book aims to change that. Through analyzing the organizational dynamic, Volume 1 brings together contributors from across Africa to provide valuable insights into how public relations contributes to organizational effectiveness on the continent. Chapters discussed include a review of public relations research in Africa, the role of the African CEO as a public relations activist, the use of social and digital media in public relations, the measurement and evaluation of communication programs, and the implications of the fourth industrial revolution on public relations practice in Africa. Providing important pathways and overviews of public relations management in Africa, this volume not only highlights current practices but offers insights into the future of the practice within its evolving global landscape.

Dieses Buch betrachtet die COVID-19-Pandemie und ihre wahrscheinlichen Folgen durch ein vierdimensionales Prisma - Bestrebungen, Emotionen, Gedanken und Empfindungen, um menschliches Verhalten zu verstehen. Diese Perspektive eröffnet Möglichkeiten, die gegenwärtige Krise in eine Chance für positive Veränderungen zu verwandeln; denn die systematische Beeinflussung der verschiedenen Komponenten unseres Seins, individuell und kollektiv, beginnt mit dem Verständnis ihrer Natur und ihrer Interaktion. Über die Beeinflussung hinaus kann dieses Zusammenspiel zwischen den Dimensionen optimiert werden, was der Zweck des im Buch vorgestellten C-Core (Completion, Compassion, Creativity, Cooperation) ist. Darüber hinaus werden die vier Determinanten betrachtet, die Institutionen prägen: Prioritäten, Menschen, Positionen, Programme - das P-Puzzle. Dieses Buch verbindet Theorie und konkrete Vorschläge sowohl für politische Entscheidungsträger, die für die Gestaltung der kollektiven Landschaft verantwortlich sind, als auch für Einzelpersonen, die sich an ein neues "Normal" anpassen und es gestalten müssen. COVID-19 erinnert daran, dass die Menschen auf der ganzen Welt im Grunde genommen gleich sind. Ob die Pandemie langfristig das Beste oder das Schlimmste in den Menschen zum Vorschein bringen wird, hängt von den individuellen und kollektiven Entscheidungen ab, unser bestes individuelles und kollektives Selbst zu fördern. COVID-19 kann entweder die Lebensqualität durch ein neues Maß an Solidarität erhöhen oder die Gesellschaft auf das bloße Überleben reduzieren.

This book tells the story of women in archaeology worldwide and their dedication to advancing knowledge and human understanding. In their own voices, they present themselves as archaeologists working in academia or the private and public sector across 33 countries. The chapters in this volume reconstruct the history of archaeology while honoring those female scholars and their pivotal research who are no longer with us.Many scholars in this volume fiercely explore non-traditional research areas in archaeology. The chapters bear witness to their valuable and unique contributions to reconstructing the past through innovative theoretical and methodological approaches. In doing so, they share the inherent difficulties of practicing archaeology, not only because they, too, are mothers, sisters, and wives but also because of the context in which they are writing. This volume may interest researchers in archaeology, history of science, gender studies, and feminist theory.Chapter(s) ¿14¿ is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This research monograph examines presidential constitutional conventions and the role they play in the political systems of four Central European countries ¿ the Czech Republic, Slovakia, Hungary, and Poland. As primarily unwritten rules of constitutional practice, constitutional conventions represent political arrangements and as such are political in origin. Not only this, constitutional conventions, in general, and presidential constitutional conventions, in particular, have signi¿cant political implications. They shape both the everyday operation and character of regimes. Central Europe represents a particularly useful example on which this role of constitutional conventions can be studied and assessed.

Food, Consumption, and Masculinity in American Hardboiled Fiction draws on three related bodies of knowledge: crime fiction criticism, masculinity studies, and the cultural analysis of food and consumption practices from a critical eating studies perspective. In particular, this book focuses on food as an analytical category in the study of tough masculinity as represented in American hardboiled fiction. Through an examination of six American novels: Dashiell Hammett's The Maltese Falcon, Raymond Chandler's The Big Sleep, Leigh Brackett's No Good from a Corpse, Dorothy B. Hughes's In a Lonely Place, Jim Thompson's The Killer Inside Me, and Rex Stout's Champagne for One, this book shows how these novels reflect the gradual process of redefining consumption and consumerism in America, which traditionally has been coded as feminine. Marta Usiekniewicz shows thatfood and eating also reflect power relations and larger social and economic structures connected to class, gender, geography, sexuality, and ability, to name just a few.

This book presents high-quality cases on the actions carried out by companies to minimize the social and environmental impact of the products (goods and services) they launch on the market. It also highlights the education campaigns that promote behavioral changes and new sustainable lifestyles that have been developed by all kinds of organizations (Public Administration, NGOs, and businesses), mainly from Corporate Social Responsibility, Social Marketing, and Behavioral Economics perspectives. International cases help students learn how management and corporate strategy, and the appropriate marketing strategies, can be designed with an aim to achieve responsible consumption and create sustainable lifestyles.

This book provides prospective and practicing teachers with research insights into the mathematical difficulties of students with learning disabilities and classroom practices that address these difficulties. This linkage between research and practice celebrates teachers as learners of their own students' mathematical thinking, thus contributing an alternative view of mathematical progression in which students are taught conceptually. The research-based volume presents a unique collaboration among researchers in special education, psychology, and mathematics education from around the world. It reflects an ongoing work by members of the International Group for the Psychology of Mathematics Education (PME) and the North American Chapter of the PME Working Groups.  The authors of chapters in this book, who have been collaborating extensively over the past 7 years, are from Australia, Canada, the United Kingdom, and the United States. 

This book examines how women journalists in Malaysia negotiated male power structures, in particular structures determined by the keystone party of the ruling coalition, the United Malays National Organisation. Through both oral histories and content analysis, it looks at how women journalists in the women's pages of the newspapers found spaces to advocate for their readers. It is thus the first work to look at the importance of the women's pages in the Malay-language newspapers, and how apparently monolithic institutions of the authoritarian state hid diverse contests for resources and prestige. In this contest, the concept of news values, the perception of the reader and the ways in which women constructed themselves as journalists all come into play, and are examined here. The book contributes to the field of feminist media studies by examining how gendered newsroom practices paradoxically allowed women journalists in the women's pages more editorial freedom than those in the malestream press.

This book introduces and provides a detailed understanding of on- and off-road vehicle dynamics. It discusses classical on-road tyre mechanics, including finite element tyre modelling and validation, using a combination of theoretical and experimental data sets. Chapters explore new computational techniques that describe terrain models and combined to develop better off-road vehicle models, and focus is placed on terrain characterization and modelling, using two popular modelling techniques, as well as performance characteristics of off-road vehicles - including rolling and driven combinations, traction, and steering. The effect of multi-pass and soil compaction on tyre performance is described as well.The book presents a unique neuro-tyre model for both on-road and off-road situations, capable of computing the steering, braking characteristics, and soil compaction. Road vehicle characteristics are described, including the stability and control, roll centre and roll axis, androllover mechanics. The road vehicle braking performance is also described, including the brake components, choice of brake, and the transient load transfer. Finally, the dynamics and control of multi-wheel combat vehicles are presented and described extensively.The book is dedicated to undergraduate and graduate engineering students, in addition to researchers, and the automotive industry. As well as provide the readers with a better understanding of vehicle dynamics and soil mechanics. The book is also beneficial for automotive industries looking for a quick and reliable model to be implemented in their main software.

This book discusses terahertz (THz) wireless communication, particularly for 6G enabling technologies, including antenna design, and channel modeling with channel characteristics for the success of reliable 6G wireless communication. The authors describe THz microstrip antenna technologies with different substrates and introduce some useful substrates to reduce the conductor and substrate losses at the THz frequencies. The discussion also includes the design of the THz unit-cell microstrip antenna and the techniques to boost the microstrip antennas' gain, directivity, and impedance bandwidth (BW), which influence the wireless communication range which is highly affected by the path losses of atmospheric conditions, and transmit and receive data rates, respectively. Moreover, this book discusses the multi-beam and beamforming THz antenna technologies with the multi-user-multiple-input-multiple-output (MU-MIMO) features. Additionally, this book describes the reconfigurable capabilities, artificial intelligence, machine learning, and deep learning technologies that will influence the success of 6G wireless communication and the authors suggest a remedy for integrating multiple radios into the system-on-chip (SoC) design.

"Meningiomas are tumors that originate from the arachnoidal cap cells of the leptomeninges. With an incidence rate of 8.36 per 100, 000 population, they are the most common primary central nervous system (CNS) tumors, accounting for a third of all cases. The World Health Organization (WHO) classification has traditionally categorized meningiomas into 15 different histopathological subtypes and three clinical grades. Tumors are classified as WHO grades 1, 2 or 3 based largely on histopathological features such as mitotic activity, presence of brain invasion, and other atypical features. However, there is increasing recognition of the limitations of histopathology including but not limited to: confounding factors such as sampling bias in a heterogeneous tumor, and technical factors related to the experience of the grading pathologist. Even with careful histologic grading, there remains significant variability in recurrence rates within each tumor grade. As more studies have uncovered the molecular features of meningiomas, novel biological alterations have helped refine classification schemes that more accurately reflect patient outcomes. This book reviews the current state of knowledge on the genomic and epigenomic landscape of meningiomas in order to identify the roles of genomic aberrations on diagnosis, prognosis, and treatment of meningiomas in addition to mainstays of surgical management, radiation therapy, and potential novel chemotherapies. Written by a team of world-renowned experts in neurosurgery, neuropathology, radiology, and radiation-oncology, this book is the definitive resource on meningioma management and investigation for both clinicians and scientists alike."

This book offers a comparative perspective on the technological, economic, and political aspects of Internet development in the post-Soviet countries. In doing so, international experts analyze similarities and differences in various countries throughout the chapters.The volume consists of two parts. The chapters of the first part examine the post-Soviet area as a whole. The second part includes specific case studies on the development of the Internet, either in individual countries or in groups of countries. Countries analyzed are Estonia, Ukraine, Russia as well as three Central Asian countries: Kazakhstan, Uzbekistan and Tajikistan. Topics covered in the volume include, but are not limited to measurement, dynamics, and structure of each national Internet audience; the history of the Internet in the post-Soviet countries; development of infrastructure; Internet regulation and institutional aspects; online markets such as telecommunications, online advertising, e-commerce, and digital content; social and cultural aspects; as well as the transformation of the national media systems. This book is a must-read for students, researchers, and scholars of political science and economics, as well as policymakers and practitioners interested in a better understanding of Internet development in the post-Soviet area.

This book examines the statecraft of former UK Prime Minister, Theresa May as a means of deconstructing her leadership of the United Kingdom. Alongside the inescapable issue of Brexit that dominated her Premiership, it takes a wider view of her record in government by looking at how and why she stood for the leadership of the Conservative Party; scrutinizes her approach to economic, social, and foreign policy; interrogates her attitudes towards Northern Ireland and the DUP; and her longstanding records on race relations, LGBT+ issues, and feminism, as well as more traditional concerns such as faith, constitution, and Britishness. This volume is the first of its kind to adopt such a systematic approach in its evaluation of May¿s leadership.

This book provides an overview of the latest R&D advancements in the field of ICT technologies inherent to a New Space vision. The book presents a system-level and technology-level description of future space networking and communications. The authors also expand the vision to interplanetary networks. The book spans hardware and software technologies for future space communication networks, also considering very modern paradigms like quantum technologies and Softwarization. In the book, the word ¿space¿ is intended in a wider sense than the usual ¿satellite communications¿, including new and partially unexplored fields like quantum space communications, interplanetary communications, and extra-terrestrial Radio Access Networks (RANs). The book includes applications including Internet of Space Things, Tactile Internet/Digital twins for Space and discusses future challenges like those involved by the concept of ¿sustainable Space¿.Provides an overview of the latest R&D advancements in the field of ICT technologies inherent to a New Space vision;Considers visions and perspectives of space technology, including a through overview of satellite communications;Presents a system-level overview of future space networking and communications.

This book offers the latest research results and predictions in data protection with a special focus on post-pandemic society. This book also includes various case studies and applications on data protection. It includes the Internet of Things (IoT), smart cities, federated learning, Metaverse, cryptography and cybersecurity. Data protection has burst onto the computer security scene due to the increased interest in securing personal data. Data protection is a key aspect of information security where personal and business data need to be protected from unauthorized access and modification. The stolen personal information has been used for many purposes such as ransom, bullying and identity theft. Due to the wider usage of the Internet and social media applications, people make themselves vulnerable by sharing personal data. This book discusses the challenges associated with personal data protection prior, during and post COVID-19 pandemic. Some of these challenges are caused by the technological advancements (e.g. Artificial Intelligence (AI)/Machine Learning (ML) and ChatGPT). In order to preserve the privacy of the data involved, there are novel techniques such as zero knowledge proof, fully homomorphic encryption, multi-party computations are being deployed. The tension between data privacy and data utility drive innovation in this area where numerous start-ups around the world have started receiving funding from government agencies and venture capitalists. This fuels the adoption of privacy-preserving data computation techniques in real application and the field is rapidly evolving. Researchers and students studying/working in data protection and related security fields will find this book useful as a reference.

The book Post-Independence Development in Africa: Decolonisation and Transformation Prospects revisits the development debates and development realities in Africa. This is achieved by offering theoretical comments about post-independence development in Africa and by providing historical details pertaining to the development approaches adopted in Africa immediately after independence in the 1960s and mid-70s. Sitting at the intersection of two sets of scholarly literature, namely; literature on development and literature on development discourses and practices in Africa, the book comprises a mixture of detailed sector-specific accounts of the status of development on the continent. The chapters in the book also contribute to clarifying how the two strands of literature intersect using several case studies across Africa.

Conservation interest in moths, by far the predominant components of Lepidoptera, lags far behind that for butterflies, for which conservation practice provides many well-established lessons for extension to their near relatives. The needs of moths are at least as great, but their greater richness and variety, and far poorer documentation of diversity and biology over much of the world contribute to this lack of attention. Australiäs rich moth fauna, largely endemic and of global interest, illustrates many of the problems of developing wider interest and support for moth conservation. Numerous species (perhaps half the total fauna) are undescribed, and many are ecological specialists in restricted and vulnerable environments over small parts of the continent. Establishing their conservation status and needs whilst accepting that foundation knowledge is highly incomplete and much species-focused conservation is impracticable provides complex problems in setting priorities, based largely on wider diversity and effective advocacy. Most Australian vegetation systems, from grassland to forest and from sea-level to alpine zones, have been eroded in extent and quality since European settlement, resulting in massive habitat changes for native insects and to leave fragmented (and commonly degraded) remnants in which moths and others may persist. Recent surveys continue to increase recorded moth richness, reveal local faunal peculiarities, and indicate how assemblage changes may mirror wider environmental changes. This book is an overview of advances in documenting and interpreting moth diversity and ecology, to show how information from better-studied moth faunas can help in planning conservation of Australiäs moths through measures such as understanding the moths themselves by increased surveys and study, the factors influencing their diversity and wellbeing, and how such threats may be countered through increased coordinated conservation interest, commitment and management.

This book provides an account of weak convergence theory, empirical processes, and their application to a wide variety of problems in statistics. The first part of the book presents a thorough treatment of stochastic convergence in its various forms. Part 2 brings together the theory of empirical processes in a form accessible to statisticians and probabilists. In Part 3, the authors cover a range of applications in statistics including rates of convergence of estimators; limit theorems for M¿ and Z¿estimators; the bootstrap; the functional delta-method and semiparametric estimation. Most of the chapters conclude with ¿problems and complements.¿ Some of these are exercises to help the reader¿s understanding of the material, whereas others are intended to supplement the text. This second edition includes many of the new developments in the field since publication of the first edition in 1996: Glivenko-Cantelli preservation theorems; new bounds on expectations ofsuprema of empirical processes; new bounds on covering numbers for various function classes; generic chaining; definitive versions of concentration bounds; and new applications in statistics including penalized M-estimation, the lasso, classification, and support vector machines. The approximately 200 additional pages also round out classical subjects, including chapters on weak convergence in Skorokhod space, on stable convergence, and on processes based on pseudo-observations.

This book provides information and resources to city planners and other public policy officials on the importance of smart sustainable cities and their relationship with urban knowledge-based economy. It answers important topical questions relating to urban sustainable development and human well-being, namely, how can we implement policies and programs that can make cities ¿smart¿ and boost their knowledge-based development? How can such programs reduce inequalities and enhance the environment where people live and work? The authors suggest a new approach to the creation of sustainable smart cities, not only in metropolises but also in smaller urban spaces. They advance the body of knowledge in entrepreneurship literature by examining both the European regional understanding of entrepreneurship and the quality of life and well-being at city levels. They also provide synthetic indexes to assess the relationship between perceived quality of life and entrepreneurship. This book stimulates the debate on the role of smart cities in promoting entrepreneurship, which is a currently under-investigated topic in Europe, and is of interest to a wide range of practitioners, professionals and academics in the area of well-being and quality of life research, urban studies, public policy, and sustainable development.

Dadäs Subject and Structure argues that Dadaist praxis was far more theoretically incisive than previous scholarship has indicated. The book combines theoretical frameworks surrounding ideological subject formation with critical media and genre histories in order to more closely read Dadaist techniques (e.g. montage, irony, nonsense, etc.) across multiple works. These readings reveal both Dadäs preternatural focus on the discursive aspects of subject formation¿linguistic sign, literary manifesto, photographic image, commodity form/aesthetics, which comprise the project¿s chapters¿and on Dadäs performative sabotage and subversion of them. In addition to highlighting commonalities between Dadaist works, artists, and chapters previously imagined disparate, the book shows how Dada simultaneously prefigured structuralist theories of subject formation and pre-performed post-structuralist critiques of those theories.