Bücher veröffentlicht von Springer International Publishing

"A lot of hard-won knowledge is laid out here in a brief but informative way. Every topic is well referenced, with citations from both the primary literature and relevant resources from the internet." Review of first edition from Nature Chemical BiologyWritten by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to start transforming their basic research discoveries into novel drugs. Often many potentially transformative basic science discoveries are not pursued because they are deemed ¿too early¿ to attract industry interest. This comprehensive book lays out simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest.Each chapter broadly discusses an important topic in drug development, from discovery, optimization and preclinical studies through clinical trial design, regulatory issues and marketing assessments. After the practical overview provided here, the reader is encouraged to consult more detailed texts on specific topics of interest.The SPARK model has been adopted in over 60 institutions on six continents, and the program has been honored with multiple awards including the 2020 Xconomy Award for Ecosystem Development, the 2020 Cures Within Reach Award for Patient Impact Research, and the 2022 California Life Sciences Pantheon Award for Academia, Non-Profits, & Research.The new edition updates every chapter with the latest developments since the 2014 publication of the first edition.

Samuel Beckett and Catastrophe is a groundbreaking collection of original essays that explore the relation between Samuel Beckett and catastrophe in terms of war, the Holocaust, nuclear disasters and ecological crisis. Responding to the post-catastrophic situations in the twentieth century, Beckett created characters who often seem to have been through an unknown catastrophe. Although the importance of catastrophe in Beckett has been noted sporadically, there has been no substantial attempt to discuss his aesthetics and work in relation to it. This collection will therefore serve as the first sustained study to explore the theme of catastrophe in Beckett and will be a highly significant contribution to Beckett studies.Chapter ¿Slow Violence and Slow Going: Encountering Beckettin the Time of Climate Catastrophe¿ is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Pattern analysis is a powerful method that changed dermatopathology, nowadays an indispensable tool in the diagnostic workup of inflammatory and neoplastic lesions. The diagnosis of melanocytic lesions can also be mastered by pattern analysis, which is the link between pathology, dermatoscopy, and clinical dermatology and supports the integration of all views. The histopathologic diagnosis of melanocytic lesions can be challenging for novices and experts alike. While classifications of melanocytic lesions come and go, pattern analysis is timeless; it can be assigned to any classification, current or future, and provides a framework that allows to address complex and uncertain cases in a repeatable manner. While uncertainty cannot be totally eliminated, pattern analysis helps to express this uncertainty in a meaningful way. Written by expert dermatopathologists with experience in dermatoscopy, this book is dedicated to young colleagues and to those who have not yet settled on one of the competing schools of thought; it is intended as a practical guide to help making correct observations, to describe them with a well-defined terminology, and to yield critical decisions in the face of incomplete or conflicting information. The illustrations contained in the volume are all original pictures in high-quality and full-color: reproductions of histopatological cuts in low and high magnification will assist pathologists, dermatologists, and dermatopathologists in interpreting histological slides of melanocytic skin lesions.

This book serves as a critical resource for educators across various roles and contexts who are interested in Holocaust education that is both historically sound and practically relevant. As a collection, it pulls together a diverse group of scholars to share their research and experiences. The volume endeavors to address topics including the nature and purpose of Holocaust education, how our understanding of the Holocaust has changed, and resources we can use with learners. These themes are consistent across the chapters, making for a comprehensive exploration of learning through the Holocaust today and in the future.

This book untangles the theory and practice of employee engagement in nonprofit organizations. It examines the antecedents, dimensions, and consequences of employee engagement while providing evidence-based context specific models for the deployment of employee engagement to facilitate how individuals and teams contribute to and enhance organizational performance and community outcomes in nonprofit organizations. Alongside the theoretical aspects are concrete examples of how to develop, implement and manage employee engagement in nonprofit employment relations and HR practices. Facilitating understanding of aspects of engagement that are unique to nonprofit organizations, this work offers researchers and students a comprehensive analysis of models that explain the role of the environment, the characteristics of employees and the organization in the dimensions of employee engagement in nonprofit organizations.

This book offers an appraisal of oratory, old and new, relating former discourse practice to a specific sub-set of contemporary, digital practices. The author explores the interface between language and society, providing an interdisciplinary study at the crossroads of discourse, linguistics, communication and rhetoric. The comparisons she draws are particularly pertinent in light of the steep rise in presentations given during video-conferences, webinars, and other online events during the COVID-19 pandemic, an event which accelerated previous moves towards digital communication and which is likely to have a long-term impact on communication styles. This book will be of interest to academics and students in fields including discourse analysis, applied linguistics, communication studies, digital studies and business studies.

This book provides an introduction to the broad topic of the calculus of variations. It addresses the most natural questions on variational problems and the mathematical complexities they present.Beginning with the scientific modeling that motivates the subject, the book then tackles mathematical questions such as the existence and uniqueness of solutions, their characterization in terms of partial differential equations, and their regularity. It includes both classical and recent results on one-dimensional variational problems, as well as the adaptation to the multi-dimensional case. Here, convexity plays an important role in establishing semi-continuity results and connections with techniques from optimization, and convex duality is even used to produce regularity results. This is then followed by the more classical Hölder regularity theory for elliptic PDEs and some geometric variational problems on sets, including the isoperimetric inequality andthe Steiner tree problem. The book concludes with a chapter on the limits of sequences of variational problems, expressed in terms of ¿-convergence.While primarily designed for master's-level and advanced courses, this textbook, based on its author's instructional experience, also offers original insights that may be of interest to PhD students and researchers. A foundational understanding of measure theory and functional analysis is required, but all the essential concepts are reiterated throughout the book using special memo-boxes.

An introduction to game theory, complete with step-by-step tools and detailed examples. This book offers condensed breakdowns of game-theory concepts. Specifically, this textbook provides ¿tools¿ or ¿recipes¿ to solve different classes of games.Game Theory presents the information as plainly and clearly as possible. Every chapter begins with the main definitions and concepts before diving into the applications to different settings across economics, business, and other social sciences. Chapters walk readers through algebraic steps and simplifications. This makes the text accessible for undergraduate and Masters-level students in economics and finance. Paired with the exercises published on the accompanying website, students will improve both their theoretical and practical understandings of game theory.Readers will walk away from this book understanding complete and incomplete information modelsas well as signaling games.

This book critically analyses the way in which traditional sociocultural and legal biases might be perpetuated against those with unknown ¿ or unknowable ¿ genetic ancestries. It looks to law and works of literature across differing eras and genres focussing upon such concepts as inherited stigma, illegitimacy, orphanisation, adoption, othering, reunion, and the ¿right¿ to access truths that relate to one¿s original identity. Law¿s role in such matters is often limited (or usurped) by custom, practice, or lingering superstitious beliefs; the importance of oral and written testimony is therefore highlighted. Characters include abandoned or orphaned figures from folk and fairy tales, Romantic and Victorian monsters and heroes, Dickensian waifs, Edwardian rescue orphans, and dystopia-set ¿rebels.¿ Their insights and experiences are mirrored in various present day scenarios that speak to familial human rights abuses, not least forced adoptions and bars on accessing original information. This cross-disciplinary book drawing on Law, Literature, Sociology, Critical Adoption Studies should be of interest to those interested in and those who have been affected in some way by adoption, origin deprivation, or reunion.

Management research has traditionally assumed that leaders play an essential role in both public and private organizations and are required for a business to run smoothly. However, more recently, a vein of critical research has claimed that leaders can do more harm than good, creating confusion and putting their reputation before production and employee wellbeing. This book asks the question - what would happen if there were no leaders? Would employees be better off without formal (or informal) leaders? And even if such a utopia were desirable, would it be realizable in practice?

This book is based on a mixed-method, longitudinal study of the transmission, production, and reception of Spanish- and Portuguese-language television in four global cities with expanding Latinx diasporic populations. The author tracks and analyzes the production practices of Spanish-language broadcasters, the highlights of news and cultural affairs coverage, changes in the shooting locations and sociocultural discourses of telenovelas (both imported from Latin America and domestically produced), the presence of SLTV in the national political sphere, and the modes of media access and opinions of over 400 viewers in Detroit, Los Angeles, Miami, and Madrid. The possibilities created by SLTV and PLTV for achieving a sense of enfranchisement are explored. Intended for a general, as well as academic reading audience.

This volume explores the South Brazilian grasslands, a unique complex of ecosystems in Brazil. Despite high biodiversity and many important ecosystem services, their biodiversity and conservation are neglected, both nationally, and globally. This book provides a state-of-the-art synthesis of knowledge on the biodiversity and its drivers in South Brazilian grasslands and associated ecosystems. Further, the book discusses conservation challenges and options, as well as management strategies that help to maintain the region¿s uniqueness. The chapters present information on biodiversity and ecological features of the region, and put this information into the context of historical and current human land uses, allowing for links to global discussions of conservation and sustainable development. Altogether, the book contains 20 chapters organized in four sections. The book is directed at researchers, students and professionals working with biodiversity and sustainable development in southern Brazil, as well as to the international scientific and conservation community interested in grasslands and associated ecosystems, particularly in tropical and subtropical regions.

This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system.Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus.Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV)where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3). This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its natural mouse host by killing off infected cells to halt replication. Over the past decade influenza A virus (IAV), herpes simplex virus (HSV) and poxvirus vaccinia (VACV) have all been shown to trigger the pathway. Herpesviruses and poxviruses also encode inhibitors of caspase-8 whose elaboration unleashes the necroptosis pathway. IAV and other RNA viruses do not encode programmed cell death inhibitors. RIPK3 is also known to induce apoptosis by recruiting RIPK1 as shown nearly a decade ago and this dual apoptosis/necroptosis induction occurs naturally during influenza A virus infection. RIPK3 is also able to induce an inflammatory response independently of programmed cell death that can predominate to drive inflammatory disease outcomes. This volume is a must-read for researchers and advanced students in immunology and virology.