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Pediatric cardiology is celebrating in the 1990s the 50th anniversary of the beginnings of the age of therapy. This informal `history' describes how the discipline grew from the era of pathologic anatomy to the dawn of therapy, the beginnings of closed heart surgery between 1939 and 1945. That dawn ushered in a remarkable half century of change and growth, leading from clinicophysiologic correlations through the start of open heart surgery in the 1950s. The text celebrates some of the achievements of this vivid and heroic age, and describes how, in the mid 1970s, new surgical and medical approaches, including prostaglandins and Doppler echocardiography, led to successful cardiac treatment in infancy, the `infant era'. Interventional cardiology and the study of childhood arrhythmias began. Now, in the 1990s, a new era emphasising molecular biology and cardiac development is growing from the tools and concepts of the past. The four eras have focused on pathologic anatomy, clinicophysiologic correlations and surgery, heart problems in infancy, and now the developing heart. In each era there have been advances in the four domains of pediatric cardiology, the heart before birth, the normal heart, heart disease and defects, and preventive cardiology. Growth in knowledge has been both episodic and dramatic, yet not a picture of unalloyed achievement. The later chapters discuss some of the problems beginning to be recognised in the new and current `developmental era'. The pioneers of pediatric cardiology, both men and women, are more than eponyms, for each used in new and original ways the tools and concepts available in their era. The interaction of tools and concepts is a theme in this book. Just as the tool of the stethoscope was vital in delineating the clinical profile of ventricular septal defect and patent ductus, the fluoroscope played a role in developing the concept of the Blalock Taussig shunt. Pioneers also includepatients and their families, and the book includes some discussion of what little is known of childhood and of the child with heart disease in the four different eras. This is a brief overview of the growth of knowledge of children's hearts from before William Harvey until our own time, and includes references to histories of cardiac surgery and to collections of classic cardiac papers. By its emphasis on the child as the central historic figure, and on the interaction of tools and concepts in the growth of knowledge, the text provides a celebratory approach to the 50th anniversary of modern pediatric cardiology.

This volume is dedicated to the memory of Albert Crumeyrolle, who died on June 17, 1992. In organizing the volume we gave priority to: articles summarizing Crumeyrolle's own work in differential geometry, general relativity and spinors, articles which give the reader an idea of the depth and breadth of Crumeyrolle's research interests and influence in the field, articles of high scientific quality which would be of general interest. In each of the areas to which Crumeyrolle made significant contribution - Clifford and exterior algebras, Weyl and pure spinors, spin structures on manifolds, principle of triality, conformal geometry - there has been substantial progress. Our hope is that the volume conveys the originality of Crumeyrolle's own work, the continuing vitality of the field he influenced, and the enduring respect for, and tribute to, him and his accomplishments in the mathematical community. It isour pleasure to thank Peter Morgan, Artibano Micali, Joseph Grifone, Marie Crumeyrolle and Kluwer Academic Publishers for their help in preparingthis volume.

Ecology and Morphology of Copepods is organized under the following general topics: Behavior, Feeding, Genetics, Horizontal Variations, Morphology, Phylogeny, Reproduction, Seasonal Changes, Vertical Distribution, plus two special sessions on copepods of the genus Acartia and cyclopid/mosquito interactions. The Maxilliped Lecture, given by Dr. Arthur G. Humes of Boston University, clearly established the importance of copepods to the earth's organic diversity. The book consists of selected research articles from the different sections. The articles published here reflect the diverse research interests of copepodologists today, and are distinguished by their high quality. Their impact will ensure that this volume is consulted by a wide range of research biologists.

In 1961 Robinson introduced an entirely new version of the theory of infinitesimals, which he called `Nonstandard analysis'. `Nonstandard' here refers to the nature of new fields of numbers as defined by nonstandard models of the first-order theory of the reals. This system of numbers was closely related to the ring of Schmieden and Laugwitz, developed independently a few years earlier. During the last thirty years the use of nonstandard models in mathematics has taken its rightful place among the various methods employed by mathematicians. The contributions in this volume have been selected to present a panoramic view of the various directions in which nonstandard analysis is advancing, thus serving as a source of inspiration for future research. Papers have been grouped in sections dealing with analysis, topology and topological groups; probability theory; and mathematical physics. This volume can be used as a complementary text to courses in nonstandard analysis, and will be of interest to graduate students and researchers in both pure and applied mathematics and physics.

Chrysophycean algae are a diverse and often abundant group of primarily freshwater phytoplankton, characterized by the endogenous formation of siliceous cysts or stomatocysts (also called statospores or statocysts). Cyst morphology is highly variable, but believed to be species-specific. Recently, cysts have received considerable attention from phycologists and especially paleoecologists who wish to use these indicators for assessments of environmental change. Nonetheless, attempts at using cysts have often been hampered by taxonomic problems. This Atlas dispels some of the mystery surrounding stomatocysts, facilitating the accurate identification of individual cyst morphotypes, and encouraging other workers to begin using these important indicators. The terminology used to describe cysts is outlined in detail, followed by detailed descriptions of cyst morphotypes, following International Statospore Working Group (ISWG) guidelines, complemented by scanning electron and light micrographs, as well as line illustrations. Any available biogeographical and ecological information is also provided. These descriptions will further accelerate the continued effort to link cyst morphotypes to the algae that produce them. For paleoecologists who wish to include stomatocysts in their studies, researchers working with living chrysophycean algae, and those interested in the morphology and ultrastructure of cyst morphotypes.

Aging is one of those subjects that many biologists feel is largely unknown. Therefore, they often feel comfortable offering extremely facile generalizations that are either unsupported or directly refuted in the experimental literature. Despite this unfortunate precedent, aging is a very broad phenomenon that calls out for integration beyond the mere collecting together of results from disparate laboratory organisms. With this in mind, Part One offers several different synthetic perspectives. The editors, Rose and Finch, provide a verbal synthesis of the field that deliberately attempts to look at aging from both sides, the evolutionary and the molecular. The articles by Charlesworth and Clark both provide population- genetic perspectives on aging, the former more mathematical, the latter more experimental. Bell takes a completely different approach, arguing that aging may not be the result of evolutionary forces. Bell's model instead proposes that aging could arise from the progressive deterioration of chronic host- pathogen interactions. This is the first detailed publication of this model. It marks something of a return to the type of aging theories that predominated in the 1950's and 1960's, theories like the somatic mutation and error catastrophe theories. We hope that the reader will be interested by the contrast in views between the articles based on evolutionary theory and that of Bell. MR. Rose and C. E. Finch (eds. ), Genetics and Evolution of Aging, 5-12, 1994. (c) 1994 Kluwer Academic Publishers. The J aniform genetics of aging 2 Michael R. Rosel & Caleb E.

Maximum entropy and Bayesian methods have fundamental, central roles in scientific inference, and, with the growing availability of computer power, are being successfully applied in an increasing number of applications in many disciplines. This volume contains selected papers presented at the Thirteenth International Workshop on Maximum Entropy and Bayesian Methods. It includes an extensive tutorial section, and a variety of contributions detailing application in the physical sciences, engineering, law, and economics. Audience: Researchers and other professionals whose work requires the application of practical statistical inference.

Automation and Environmental Control in Plant Tissue Culture rigorously explores the new challenges faced by modern plant tissue culture researchers and producers worldwide: issues of cost efficiency, automation, control, and optimization of the in vitro microenvironment. This book achieves a critical balance between the economic, engineering and biological viewpoints, and presents well-balanced, unique, and clearly organized perspectives on current initiatives in the tissue culture arena. Each chapter offers guidelines leading towards an exhaustive, unprecedented level of control over in vitro growth, based on emerging technologies of robotics, machine vision, environmental sensors and regulation, and systems analysis. Unlike other tissue culture books which focus on specific crops and techniques, this book spans the broad range of major tissue culture production systems, and advances evidence on how some underrated aspects of the process actually determine the status of the end product. Key researchers from industry and academia have joined to give up-to-date research evidence and analysis. The collection comprises an essential reference for industrial-scale tissue culture producers, as well as any researcher interested in optimizing in vitro production.

In 1971, the late Dr. J. Kolek of the Institute of Botany, Bratislava, organized the first International Symposium devoted exclusively to plant roots. At that time, perhaps only a few of the participants, gathered together in Tatranska Lomnica, sensed that a new era of root meetings was beginning. Nevertheless, it is now clear that Dr. Kolek's action, undertaken with his characteristic enormous enthusiasm, was rather pioneering, for it started a series a similar meetings. Moreover, what was rather exceptional at the time was the fact that the meeting was devoted to the functioning of just a single organ, the root. One possible reason for the unexpected success of the original, perhaps naive, idea of a Root Symposium might lie with the fact that plant roots have always been extremely popular as experimental material for cytologists, biochemists and physiologists whishing to probe processes as diverse as cell division and solute transport. Of course, the connection of roots with the rest of the plant is not forgotten either. This wide variety of disciplines is now coupled with the development of increasingly sophisticated experimental techniques to study some of these old problems. These factors undoubtedly contribute to the necessity of continuing the tradition of the root symposia. The common theme of root function gives, in addition, a certain unity to all these diverse activities.

It is generally acknowledged today that the most effective strategy for toxic and hazardous waste management is: reduction, reuse and recycle. However, to date most of the activity has been in treatment technologies. This book focuses on recent technological issues commercially available or in various stages of implementation. Developments in the U.S. and Europe in the area of waste management policy and regulation are also examined since management and remediation have usually been conducted in response to regulatory requirements. This book serves as a state of the art resource on technologies and methodologies for the environmental protection manager involved in decisions concerning the management of toxic and hazardous waste.

This book contains the courses given at the Third School on Statistical Physics and Cooperative Systems held at Santiago, Chile, from 14th to 18th December 1992. The main idea of this periodic school was to bring together scientists work- with recent trends in Statistical Physics. More precisely ing on subjects related related with non linear phenomena, dynamical systems, ergodic theory, cellular au- tomata, symbolic dynamics, large deviation theory and neural networks. Scientists working in these subjects come from several areas: mathematics, biology, physics, computer science, electrical engineering and artificial intelligence. Recently, a very important cross-fertilization has taken place with regard to the aforesaid scientific and technological disciplines, so as to give a new approach to the research whose common core remains in statistical physics. Each contribution is devoted to one or more of the previous subjects. In most cases they are structured as surveys, presenting at the same time an original point of view about the topic and showing mostly new results. The expository text of Fran