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* . . . . At last the doctor will be freed from the tedious interpretation of screens and photographs. Instead, he will examine and scan through his patient directly. Wearing optical-shutter spectacles and aiming a pulsed laser torch, he will be able to peer at the beating heart, study the movement of a joint or the flexing of a muscle, press on suspect areas to see how the organs beneath respond, check that pills have been correctly swallowed or that an implant is savely in place, and so on. A patient wearing white cotton or nylon clothes that scatter but hardly absorb light, may not even have to undress . . . . *. David Jones, Nature (1990) 348:290 Optical imaging of the brain is a rapidly growing field of heterogenous techniques that has attracted considerable interest recently due to a number of theoretical advantages in comparison with other brain imaging modalities: it uses non- ionizing radiation, offers high spatial and temporal resolution, and supplies new types of metabolic and functional information. From a practical standpoint it is important that bedside examinations seem feasible and that the implementations will be considerably less expensive compared with competing techniques. In October 1991, a symposium was held at the Eibsee near Garmisch, Germany to bring together the leading scientists in this new field.

This conference and monograph were the result of many collective efforts. The whole concept was formulated one early Wednesday morning at our weekly research meeting at Children's Hospital in our division of urology. We have been most fortunate to have a close collaboration with Bob Levin, Ed Macarak, and Pam Howard who have helped steer the course of our division's growing interest in basic science. At our weekly meetings our laboratory fellow will summarize their current work. Other ongoing areas of investigation in our labs and elsewhere are discussed. We have always made an effort to try and understand what other groups are doing who are working in the area of bladder smooth muscle research. It occurred to us that the best way to really know what everyone working in this field was doing would be to sponsor a 2-day meeting where we could all gather to discuss our ongoing work. A major limitation of the annual meeting of the American Urologic Association or the urology section of the American Academy of Pediatrics is that the scientfic sessions are limited as these are meant to be primarily clinical meetings (as they should be). For this reason the idea of a meeting devoted solely to research about the urinary bladder had great appeal. In addition to allowing for longer presentations than the standard 5 to 7 minutes, every effort would be made to encourage a dialogue amongst the presenters and the audience.

In the past 15 years much evidence has accumulated which indicates the paramount importance of sensory nerves in reg- ulating functions of the gastrointestinal tract. In parallel, the attention of researchers in this field has been increas- ingly attracted to the role played by neuropeptides in the normal and diseased gut. Basic research on the peculiar properties of capsaicin, the pungent ingredient from plants of the genus Capsicum, has allowed the gap between these two areas of research to be bridged. Sincethen, the study of gut afferents and neuropeptides has become more and more interconnected and recognized as a major avenue to understand- ing the pathophysiology of various human diseases. It is widely recognized that a certain subset of primary afferents synthesize, store and release neuropeptides (such as tachykin- nins and calcitonin gene-related peptide) from their central and peripheral endings, the latter being widely distributed in the alimentary canal and related organs (liver, pancreas). The First International Meeting on Sensory Nerves and Neuropeptides in Gastroenterology, held in Florence from December 4-5, 1989, sponsored and organized by Fondazione Internazionale Menarini, aimed to focus the current status of research in this field. The contributions presented at the meeting and in this book delineate a suggestive scenario in which sensory nerves of the gut, and the multiple messages they carry through the release of neuropeptides, are to be considered as a major target for the development of new drugs potentially useful in a number of diseases of the gastro- intestinal tract.

Proceedings of the Tenth International Cryogenic Materials Conference (ICMC) held in Albuquerque, New Mexico, July 12-16, 1993.

Multimedia computing has emerged in the last few years as a major area of research. Multimedia computer systems have opened a wide range of applications by combining a variety of information sources, such as voice, graphics, animation, images, audio, and full-motion video. Looking at the big picture, multimedia can be viewed as the merging of three industries: the computer, communications, and broadcasting industries. Research and development efforts in multimedia computing can be divided into two areas. As the first area of research, much effort has been centered on the stand-alone multimedia workstation and associated software systems and tools, such as music composition, computer-aided education and training, and interactive video. However, the combination of multimedia computing with distributed systems offers even greater potential. New applications based on distributed multimedia systems include multimedia information systems, collaborative and videoconferencing systems, on-demand multimedia services, and distance learning. Multimedia Tools and Applications is one of two volumes published by Kluwer, both of which provide a broad introduction to this fast moving area. This book covers selected tools applied in multimedia systems and key multimedia applications. Topics presented include multimedia application development techniques, techniques for content-based manipulation of image databases, techniques for selection and dissemination of digital video, and tools for digital video segmentation. Selected key applications described in the book include multimedia news services, multimedia courseware and training, interactive television systems, digital video libraries, multimedia messaging systems, and interactive multimedia publishing systems. The second book, Multimedia Systems and Techniques, covers fundamental concepts and techniques used in multimedia systems. The topics include multimedia objects and related models, multimedia compression techniques and standards, multimedia interfaces, multimedia storage techniques, multimedia communication and networking, multimedia synchronization techniques, multimedia information systems, scheduling in multimedia systems, and video indexing and retrieval techniques. Multimedia Tools and Applications, along with its companion volume, is intended for anyone involved in multimedia system design and applications and can be used as a textbook for advanced courses on multimedia.

Input/Output in Parallel and Distributed Computer Systems has attracted increasing attention over the last few years, as it has become apparent that input/output performance, rather than CPU performance, may be the key limiting factor in the performance of future systems. This I/O bottleneck is caused by the increasing speed mismatch between processing units and storage devices, the use of multiple processors operating simultaneously in parallel and distributed systems, and by the increasing I/O demands of new classes of applications, like multimedia. It is also important to note that, to varying degrees, the I/O bottleneck exists at multiple levels of the memory hierarchy. All indications are that the I/O bottleneck will be with us for some time to come, and is likely to increase in importance. Input/Output in Parallel and Distributed Computer Systems is based on papers presented at the 1994 and 1995 IOPADS workshops held in conjunction with the International Parallel Processing Symposium. This book is divided into three parts. Part I, the Introduction, contains four invited chapters which provide a tutorial survey of I/O issues in parallel and distributed systems. The chapters in Parts II and III contain selected research papers from the 1994 and 1995 IOPADS workshops; many of these papers have been substantially revised and updated for inclusion in this volume. Part II collects the papers from both years which deal with various aspects of system software, and Part III addresses architectural issues. Input/Output in Parallel and Distributed Computer Systems is suitable as a secondary text for graduate level courses in computer architecture, software engineering, and multimedia systems, and as a reference for researchers and practitioners in industry.

Catheter-delivered therapeutic ultrasound angioplasty is a new technique for use in the treatment of obstructive vascular disease. The treatment differs from balloon angioplasty in that it has been shown experimentally to cause disintegration of calcific and fibrotic atherosclerotic plaques, thrombus dissolution and arterial vasodilation. In contrast to laser technology, ultrasound systems are relatively inexpensive and simple to use and maintain. In the clinical trials detailed in this text, ultrasound angioplasty has been shown to be feasible and safe. Ultrasound Angioplasty is a comprehensive text, addressing the theoretical, experimental and clinical issues. The international contributions reflect the excitement, interest, spirit and cooperation in the research and development of therapeutic ultrasound.

Multimedia computing has emerged in the last few years as a major area of research. Multimedia computer systems have opened a wide range of applications by combining a variety of information sources, such as voice, graphics, animation, images, audio and full-motion video. Looking at the big picture, multimedia can be viewed as the merging of three industries: computer, communications, and broadcasting industries. Research and development efforts can be divided into two areas. As the first area of research, much effort has been centered on the stand-alone multimedia workstation and associated software systems and tools, such as music composition, computer-aided education and training, and interactive video. However, the combination of multimedia computing with distributed systems offers even greater potential. New applications based on distributed multimedia systems include multimedia information systems, collaborative and video conferencing systems, on-demand multimedia services, and distance learning. Multimedia Systems and Techniques is one of two volumes published by Kluwer, both of which provide a broad introduction into this fast moving area. The book covers fundamental concepts and techniques used in multimedia systems. The topics include multimedia objects and related models, multimedia compression techniques and standards, multimedia interfaces, multimedia storage techniques, multimedia communication and networking, multimedia synchronization techniques, multimedia information systems, scheduling in multimedia systems, and video indexing and retrieval techniques. Multimedia Systems and Techniques, together with its companion volume, Multimedia Tools and Applications, is intended for anyone involved in multimedia system design and applications and can be used as a textbook for advanced courses on multimedia.

Researchers working with nonlinear programming often claim "e;the word is non- linear"e; indicating that real applications require nonlinear modeling. The same is true for other areas such as multi-objective programming (there are always several goals in a real application), stochastic programming (all data is uncer- tain and therefore stochastic models should be used), and so forth. In this spirit we claim: The word is multilevel. In many decision processes there is a hierarchy of decision makers, and decisions are made at different levels in this hierarchy. One way to handle such hierar- chies is to focus on one level and include other levels' behaviors as assumptions. Multilevel programming is the research area that focuses on the whole hierar- chy structure. In terms of modeling, the constraint domain associated with a multilevel programming problem is implicitly determined by a series of opti- mization problems which must be solved in a predetermined sequence. If only two levels are considered, we have one leader (associated with the upper level) and one follower (associated with the lower level).

The scientists and engineers of today are relentless in their continuing study and analysis of the world about us from the microcosm to the macrocosm. A central purpose of this study is to gain sufficient scientific information and insight to enable the development of both representative and useful models of the superabundance of physical processes that surround us. The engineers need these models and the associated insight in order to build the information processing systems and control systems that comprise these new and emerging technologies. Much of the early modeling work that has been done on these systems has been based on the linear time-invariant system theory and its extensive use of Fourier transform theory for both continuous and discrete systems and signals. However many of the signals arising in nature and real systems are neither stationary nor linear but tend to be concentrated in both time and frequency. Hence a new methodology is needed to take these factors properly into account.

Recent Advances in Robot Learning contains seven papers on robot learning written by leading researchers in the field. As the selection of papers illustrates, the field of robot learning is both active and diverse. A variety of machine learning methods, ranging from inductive logic programming to reinforcement learning, is being applied to many subproblems in robot perception and control, often with objectives as diverse as parameter calibration and concept formulation. While no unified robot learning framework has yet emerged to cover the variety of problems and approaches described in these papers and other publications, a clear set of shared issues underlies many robot learning problems. Machine learning, when applied to robotics, is situated: it is embedded into a real-world system that tightly integrates perception, decision making and execution. Since robot learning involves decision making, there is an inherent active learning issue. Robotic domains are usually complex, yet the expense of using actual robotic hardware often prohibits the collection of large amounts of training data. Most robotic systems are real-time systems. Decisions must be made within critical or practical time constraints. These characteristics present challenges and constraints to the learning system. Since these characteristics are shared by other important real-world application domains, robotics is a highly attractive area for research on machine learning. On the other hand, machine learning is also highly attractive to robotics. There is a great variety of open problems in robotics that defy a static, hand-coded solution. Recent Advances in Robot Learning is an edited volume of peer-reviewed original research comprising seven invited contributions by leading researchers. This research work has also been published as a special issue of Machine Learning (Volume 23, Numbers 2 and 3).

With the rapid growth of bandwidth demand from network users and the advances in optical technologies, optical networks with multiterabits- per-second capacity has received significant interest from both researchers and practitioners. Optical networks deployment raises a number of challenging problems that require innovative solutions, including net- work architectures, scalable and fast network management, resource- efficient routing and wavelength assignment algorithms, QoS support and scheduling algorithms, and switch and router architectures. In this book, we put together some important developments in this exiting area during last several years. Some of the articles are research papers and some are surveys. All articles were reviewed by two reviewers. The paper, "e;On Dynamic Wavelength Assignment in WDM Optical Networks,"e; by Alanyali gives an overview of some issues in the analy- sis and synthesis of dynamic wavelength assignment policies for optical WDM networks and illustrates a new method of analysis. The paper by Ellinas and Bala, "e;Wavelength Assignment Algorithms for WDM Ring Architectures,"e; presents two optimal wavelength assignment algorithms that assign the minimum number of wavelengths between nodes on WDM rings to achieve full mesh connectivity. In the paper, "e;Optimal Placement of Wavelength Converters in WDM Networks for Parallel and Distributed Computing Systems,"e; Jia et al.

There has been much recent progress in global optimization algo- rithms for nonconvex continuous and discrete problems from both a theoretical and a practical perspective. Convex analysis plays a fun- damental role in the analysis and development of global optimization algorithms. This is due essentially to the fact that virtually all noncon- vex optimization problems can be described using differences of convex functions and differences of convex sets. A conference on Convex Analysis and Global Optimization was held during June 5 -9, 2000 at Pythagorion, Samos, Greece. The conference was honoring the memory of C. Caratheodory (1873-1950) and was en- dorsed by the Mathematical Programming Society (MPS) and by the Society for Industrial and Applied Mathematics (SIAM) Activity Group in Optimization. The conference was sponsored by the European Union (through the EPEAEK program), the Department of Mathematics of the Aegean University and the Center for Applied Optimization of the University of Florida, by the General Secretariat of Research and Tech- nology of Greece, by the Ministry of Education of Greece, and several local Greek government agencies and companies. This volume contains a selective collection of refereed papers based on invited and contribut- ing talks presented at this conference. The two themes of convexity and global optimization pervade this book. The conference provided a forum for researchers working on different aspects of convexity and global opti- mization to present their recent discoveries, and to interact with people working on complementary aspects of mathematical programming.

The International Conference on Differential Equations and Nonlinear Mechanics was hosted by the University of Central Florida in Orlando from March 17-19, 1999. One of the conference days was dedicated to Professor V. Lakshmikantham in th honor of his 75 birthday. 50 well established professionals (in differential equations, nonlinear analysis, numerical analysis, and nonlinear mechanics) attended the conference from 13 countries. Twelve of the attendees delivered hour long invited talks and remaining thirty-eight presented invited forty-five minute talks. In each of these talks, the focus was on the recent developments in differential equations and nonlinear mechanics and their applications. This book consists of 29 papers based on the invited lectures, and I believe that it provides a good selection of advanced topics of current interest in differential equations and nonlinear mechanics. I am indebted to the Department of Mathematics, College of Arts and Sciences, Department of Mechanical, Materials and Aerospace Engineering, and the Office of International Studies (of the University of Central Florida) for the financial support of the conference. Also, to the Mathematics Department of the University of Central Florida for providing secretarial and administrative assistance. I would like to thank the members of the local organizing committee, Jeanne Blank, Jackie Callahan, John Cannon, Holly Carley, Brad Pyle, Pete Rautenstrauch, and June Wingler for their assistance. Thanks are also due to the conference organizing committee, F. H. Busse, J. R. Cannon, V. Girault, R. H. J. Grimshaw, P. N. Kaloni, V.

Hardware description languages (HDL) such as VHDL and Verilog have found their way into almost every aspect of the design of digital hardware systems. Since their inception they gradually proved to be an essential part of modern design methodologies and design automation tools, ever exceeding their original goals of being description and simulation languages. Their use for automatic synthesis, formal proof, and testing are good examples. So far, HDLs have been mainly dealing with digital systems. However, integrated systems designed today require more and more analog parts such as A/D and D/A converters, phase locked loops, current mirrors, etc. The verification of the complete system therefore asks for the use of a single language. Using VHDL or Verilog to handle analog descriptions is possible, as it is shown in this book, but the real power is coming from true mixed-signal HDLs that integrate discrete and continuous semantics into a unified framework. Analog HDLs (AHDL) are considered here a subset of mixed-signal HDLs as they intend to provide the same level of features as HDLs do but with a scope limited to analog systems, possibly with limited support of discrete semantics. Analog and Mixed-Signal Hardware Description Languages covers several aspects related to analog and mixed-signal hardware description languages including: The use of a digital HDL for the description and the simulation of analog systems The emergence of extensions of existing standard HDLs that provide true analog and mixed-signal HDLs. The use of analog and mixed-signal HDLs for the development of behavioral models of analog (electronic) building blocks (operational amplifier, PLL) and for the design of microsystems that do not only involve electronic parts. The use of a front-end tool that eases the description task with the help of a graphical paradigm, yet generating AHDL descriptions automatically. Analog and Mixed-Signal Hardware Description Languages is the first book to show how to use these new hardware description languages in the design of electronic components and systems. It is necessary reading for researchers and designers working in electronic design.

Models in System Design tracks the general trend in electronics in terms of size, complexity and difficulty of maintenance. System design is by nature combined with prototyping, mixed domain design, and verification, and it is no surprise that today's modeling and models are used in various levels of system design and verification. In order to deal with constraints induced by volume and complexity, new methods and techniques have been defined. Models in System Design provides an overview of the latest modeling techniques for use by system designers. The first part of the book considers system level design, discussing such issues as abstraction, performance and trade-offs. There is also a section on automating system design. The second part of the book deals with some of the newest aspects of embedded system design. These include co-verification and prototyping. Finally, the book includes a section on the use of the MCSE methodology for hardware/software co-design. Models in System Design will help designers and researchers to understand these latest techniques in system design and as such will be of interest to all involved in embedded system design.

Despite the growing interest in Real-Time Database Systems, there is no single book that acts as a reference to academics, professionals, and practitioners who wish to understand the issues involved in the design and development of RTDBS. Real-Time Database Systems: Issues and Applications fulfills this need. This book presents the spectrum of issues that may arise in various real-time database applications, the available solutions and technologies that may be used to address these issues, and the open problems that need to be tackled in the future. With rapid advances in this area, several concepts have been proposed without a widely accepted consensus on their definitions and implications. To address this need, the first chapter is an introduction to the key RTDBS concepts and definitions, which is followed by a survey of the state of the art in RTDBS research and practice. The remainder of the book consists of four sections: models and paradigms, applications and benchmarks, scheduling and concurrency control, and experimental systems. The chapters in each section are contributed by experts in the respective areas. Real-Time Database Systems: Issues and Applications is primarily intended for practicing engineers and researchers working in the growing area of real-time database systems. For practitioners, the book will provide a much needed bridge for technology transfer and continued education. For researchers, this book will provide a comprehensive reference for well-established results. This book can also be used in a senior or graduate level course on real-time systems, real-time database systems, and database systems or closely related courses.

Multimedia Database Management Systems brings together in one place important contributions and up-to-date research results in this important area. Multimedia Database Management Systems serves as an excellent reference, providing insight into some of the most important research issues in the field.

Angioplasty has completely transformed the treatment of coronary artery disease and is widely used, with more than 800,000 procedures performed worldwide per year. However, the enthusiasm for angioplasty is shadowed by restenosis, which remains a critical problem after the procedure, resulting in clinical recurrence in over a third of patients. Recently, the mechanisms of restenosis have been completely reappraised with an enriched understanding that the original concept of neointimal hyperplasia may not be accounting for the bulk of the problem. There is a desperate need to heighten understanding of the remodeling process at the molecular, cellular, and arterial level. Vascular remodeling is a well established concept in the field of atherosclerosis and hypertension, but only in recent years has its applicability to the field of restenosis become pivotal. Accordingly, the editors perceived the need to assemble the first book dedicated to the concept of coronary artery remodeling in restenosis, in order to clearly review the experiments leading to the remodeling hypothesis and integrate this with the neointimal hyperplasia (tumor) model for the development of the restenotic lesion. The authors of this book present their experience to facilitate the understanding of the mechanisms for coronary restenosis and remodeling. The various experimental models, clinical issues, and basic mechanisms are reviewed in detail, resulting in a fresh approach to a vexing clinical problem. Arterial Remodeling: A Critical Factor in Restenosis will be useful to the physician and trainee who have an interest in restenosis, and specifically in the major pathophysiologic process which determines the fate of arterial healing in patients following percutaneous coronary revascularization. It is hoped that this book will lay the foundation for more effective therapies that will reduce the chance of constrictive remodeling and improve the long-term efficacy of non-surgical coronary revascularization in the future.

Real-time systems are defined as those for which correctness depends not only on the logical properties of the produced results, but also on the temporal properties of these results. In a database, real-time means that in addition to typical logical consistency constraints, such as a constraint on a data item's value, there are constraints on when transactions execute and on the `freshness' of the data transactions access. The challenges and tradeoffs faced by the designers of real-time database systems are quite different from those faced by the designers of general-purpose database systems. To achieve the fundamental requirements of timeliness and predictability, not only do conventional methods for scheduling and transaction management have to be redesigned, but also new concepts that have not been considered in conventional database systems or in real-time systems need to be added. Real-Time Database and Information Systems: Research Advances is devoted to new techniques for scheduling of transactions, concurrency management, transaction logging, database languages, and new distributed database architectures. Real-Time Database and Information Systems: Research Advances is primarily intended for practicing engineers and researchers working in the growing area of real-time database and information retrieval systems. For practitioners, the book will provide a much needed bridge for technology transfer and continued education. For researchers, the book will provide a comprehensive reference for well-established results. The book can also be used in a senior or graduate level course on real-time systems, real-time database systems, and database systems, or closely related courses.

There is broad interest in feature extraction, construction, and selection among practitioners from statistics, pattern recognition, and data mining to machine learning. Data preprocessing is an essential step in the knowledge discovery process for real-world applications. This book compiles contributions from many leading and active researchers in this growing field and paints a picture of the state-of-art techniques that can boost the capabilities of many existing data mining tools. The objective of this collection is to increase the awareness of the data mining community about the research of feature extraction, construction and selection, which are currently conducted mainly in isolation. This book is part of our endeavor to produce a contemporary overview of modern solutions, to create synergy among these seemingly different branches, and to pave the way for developing meta-systems and novel approaches. Even with today's advanced computer technologies, discovering knowledge from data can still be fiendishly hard due to the characteristics of the computer generated data. Feature extraction, construction and selection are a set of techniques that transform and simplify data so as to make data mining tasks easier. Feature construction and selection can be viewed as two sides of the representation problem.

In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.

Major advances in computing are occurring at an ever-increasing pace. This is especially so in the area of high performance computing (HPC), where today's supercomputer is tomorrow's workstation. High Performance Computing Systems and Applications is a record of HPCS'98, the 12th annual Symposium on High Performance Computing Systems and Applications. The quality of the conference was significantly enhanced by the high proportion of keynote and invited speakers. This book presents the latest research in HPC architecture, networking, applications and tools. Of special note are the sections on computational biology and physics. High Performance Computing Systems and Applications is suitable as a secondary text for a graduate-level course on computer architecture and networking, and as a reference for researchers and practitioners in industry.

The most important use of computing in the future will be in the context of the global "e;digital convergence"e; where everything becomes digital and every- thing is inter-networked. The application will be dominated by storage, search, retrieval, analysis, exchange and updating of information in a wide variety of forms. Heavy demands will be placed on systems by many simultaneous re- quests. And, fundamentally, all this shall be delivered at much higher levels of dependability, integrity and security. Increasingly, large parallel computing systems and networks are providing unique challenges to industry and academia in dependable computing, espe- cially because of the higher failure rates intrinsic to these systems. The chal- lenge in the last part of this decade is to build a systems that is both inexpensive and highly available. A machine cluster built of commodity hardware parts, with each node run- ning an OS instance and a set of applications extended to be fault resilient can satisfy the new stringent high-availability requirements. The focus of this book is to present recent techniques and methods for im- plementing fault-tolerant parallel and distributed computing systems. Section I, Fault-Tolerant Protocols, considers basic techniques for achieving fault-tolerance in communication protocols for distributed systems, including synchronous and asynchronous group communication, static total causal order- ing protocols, and fail-aware datagram service that supports communications by time.

Process Technology brings together in one place important contributions and up-to-date research results in this fast moving area. Process Technology serves as an excellent reference, providing insight into some of the most challenging research issues in the field.

Mobile Data Management and Applications brings together in one place important contributions and up-to-date research results in this fast moving area. Mobile Data Management and Applications serves as an excellent reference, providing insight into some of the most challenging research issues in the field.

It is certain that, over the next few years, data traffic will dwarf voice traffic on telecommunications networks. Growth in data-traffic volumes far exceeds that for voice, and is driven by increased use of applications such as e-mail attachments, remote printing and fileserver access, and the now omnipresent World Wide Web. The growth of data networking to connect computers with each other and with their peripheral devices began in earnest in the 1970s, took off in the 1980s and exploded in the 1990s. The early 21st century will see ever faster, more cost- effective networks providing flexible data access into ever more businesses and homes. Since the 1970s there have been great advances in technology. For the past twenty years the processing power of computers has continued to grow with no hint of slowing - recall the oft-cited Moore's Law claiming that this power doubles every 18 months. Advances in the data networking equipment required to support the data traffic generated have been enormous. The pace of development from early X. 25 and modem technology through to some of the advanced equipment functionality now available is breathtaking - it is sometimes hard to believe that the practical router is barely ten years old! This book provides an overview of the advanced data networking field by bringing together chapters on local area networks, wide area networks and their application.

Parallel Numerical Computations with Applications contains selected edited papers presented at the 1998 Frontiers of Parallel Numerical Computations and Applications Workshop, along with invited papers from leading researchers around the world. These papers cover a broad spectrum of topics on parallel numerical computation with applications; such as advanced parallel numerical and computational optimization methods, novel parallel computing techniques, numerical fluid mechanics, and other applications related to material sciences, signal and image processing, semiconductor technology, and electronic circuits and systems design. This state-of-the-art volume will be an up-to-date resource for researchers in the areas of parallel and distributed computing.

This book is timely and challenging. Within its pages are commentaries and opinions on the scientific background and explanatory ideas for a complex of symptoms and investigations known as syndrome X. The commonest cause by far of angina pectoris is coronary artery obstruction due to atheromatous lesions both within the wall of the artery and intruding into the lumen; in such patients it is expected that there maybe ST segment depression on atrial pacing or on an exercise test indicating myocardial ischemia. Syndrome X was a term first used in an editorial written by Kemp in 1973. He was referring to patients in group X in a paper from Arbogast and Bourassa. Patients in group X had three features, namely angina as judged on a clinical history, alterations of the ST segment on the electrocardiogram during atrial pacing and smooth unobstructed coronary arteries (presumed normal) as assessed by the technique of coronary angiography. The changes on the electrocardiogram, conventionally indicative of myocardial ischemia, could not be explained on the basis of any abnormality of the coronary arteries and Kemp named the complex of fmdings syndrome X because of this seeming paradox and the lack of a single explanation. In the last thirty-one years there has been substantial scientific interest in this syndrome giving rise to a large number of publications. The name syndrome X has led to considerable confusion. Physicians are familiar with the X chromosome and with X linked congenital disorders.