Bücher veröffentlicht von Springer Verlag GmbH

In this context, this book provides a state-of-the-art survey of the most recent advances in the field of counterterrorism and open source intelligence, demonstrating how various existing as well as novel tools and techniques can be applied in combating covert terrorist networks.

The papers in this volume address advanced nonlinear topics in the general areas of vibration mitigation and system identification, such as, methods of analysis of strongly nonlinear dyanmical systems;

Die vorliegende polydiagnostische, systematische Zwillingsstudie beweist, dass das Spektrum der Psychosen aus dem schizophrenen Formenkreis kein Krankheitskontinuum darstellt. Es besteht aus zykloiden Psychosen, unsystematischen und systematischen Schizophrenien wie sie von Karl Leonhard beschrieben wurden.

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The latest state of simulation techniques to model plasticity and fracture in crystalline materials on the nano- and microscale is presented.

The book covers the state-of-the-art treatment in modelling and experimental investigation of the mechanical behaviour of cellular and porous materials. Starting from the continuum mechanical modelling, to the numerical simulation, several important questions related to applications such as the fracture and impact behaviour are covered.

Important aspects of social networking analysis are covered in this work by combining experimental and theoretical research.

The Yearbook on Space Policy aims to be the reference publication analysingspace policy developments. Each year it presents issues and trends in space policyand the space sector as a whole. It combines in-house research and contributionsof members of the European Space Policy Research and Academic Network(ESPRAN), coordinated by ESPI.

The latest state of simulation techniques to model plasticity and fracture in crystalline materials on the nano- and microscale is presented.

This book examines management of space exploration, space settlements, the role of astronauts in the future as well as related to the encounter of extraterrestrial life. It reflects on issues related to Europe's role in conducting human exploration in space.

The authors of this book explain at length the principles of chemical kinetics and approaches to computerized calculations in modern software mathcad and maple. Numerous problems encountered in solving kinetics' calculations are provided.

The main focus of the book is to convey modern techniques applied within the range of computational mechanics of beams, plates and shells. The topics of interest are wide ranging and include computational aspects of nonlinear theories of shells and beams.

Detecting residual cognitive function in disorders of consciousness (M. SIMON, M. NICOLELIS).- SEEG-guided RF-thermocoagulation of epileptic foci: A therapeutic alternative for drug-resistant non-operable partial epilepsies (M. MAUGUIERE, M. MADEA, M.

New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process.

The book provides an introduction to the mechanics of composite materials, written for graduate students and practitioners in industry. It examines ways to model the impact event, to determine the size and severity of the damage and discusses general trends observed during experiments.

. . . . . . . . . . . . . . . . 6 Patternsofcelldeath. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Autophagy:apotentialTrojanhorseformalignantgliomas. . . . . . . . . . . . . . . . 11 Therapeuticbene?tsoftemozolomide. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Localtherapiesforglioblastomas. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Ongoingclinicaltrialsforglioblastomas. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Growthfactorreceptorinhibitors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 PI3K=Akt,mTORandNF- Binhibitors. . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Matrixmetalloproteinase(MMP)inhibitors(MMPI). . . . . . . . . . . . . . . . . . . 18 Angiogenesistargeting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Cellularandvaccinationtherapies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Genetherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Reducingmalignantgliomacellmotilityinordertorestore pro-apoptoticdrugsensitivity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Thesodiumpumpconstitutesapotentialtargettocombat malignantgliomas. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 Thesodiumpump. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 Cardiotonicsteroids:ligandsofthesodiumpump. . . . . . . . . . . . . . . . . . . . 24 VIII Contents Thesodiumpumpisinvolvedincancercellproliferation, migrationanddeath. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 Braintumorstemcellsapotentialtargettocombatmalignantgliomas. . . . . . . 26 Conclusions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 References. . . . . . . . . . . . . . . .

An up-to-date text on climate change focussing on technical solutions for the most important and climate relevant economic sectors is presented. The first of three sections covers the scientific basis of climate change and the instruments to prevent or reduce negative climate effects.

The book focuses on the fluid dynamics of cavitation with special reference to high power density turbopumps, where it represents the major source of performance and life degradation.

Topics of this book span the range from spatial and temporal discretization techniques for contact and impact problems with small and finite deformations over investigations on the reliability of micromechanical contact models over emerging techniques for rolling contact mechanics to homogenization methods and multi-scale approaches in contact problems. Furthermore, solution algorithms for single- and multi-processor computing environments, enabling methods that span from multi-contact to multi-scale approaches are discussed together with numerical experiments related to soil mechanics using discontinuous deformation analysis.

genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale protein annotation of function and structure, annotation and prediction of protein interactions, and the organization and annotation of molecular networks and biochemical pathways.

This is the first book to cover minimal-invasive treatment of osteoporotic, tumorous and traumatic vertebral fractures in the English language.

Recent investigations have highlighted the similarities between turbulence in cryogenic fluids at temperatures close to absolute zero, in particular superfluid helium, and turbulence in ordinary fluids.

The articles in this book describe new developments in the area of structural testing, particularly those based upon the principle of fusing numerical and experimental methods such as real-time dynamic substructuring and hardware-in-the loop testing.

Advanced materials play a crucial role in modern engineering applications where they are often exposed to complex loading and environmental conditions.

African horse sickness virus is a double-stranded RNA virus which causes a non-contagious, infectious arthropod-borne disease of equines and occasionally dogs.

Peripheral nerve problems and problems concerning differential diagnosis in special situations such as between radicular and peripheral nerve trunk lesions are discussed, pinpointing the significance of different diagnostic tools.

Nonsmooth mechanics is a relatively complex field and requires a good knowledge of mechanics as well as a good background in some parts of modern mathematics. It includes contributions that cover mechanical aspects as well as the mathematical and numerical treatment.

Papers in this book provide a state-of-the-art examination of waves in pre-stressed materials. These topics include the mathematical modeling of incremental material response (elastic and inelastic), an analysis of the governing differential equations, and boundary-value problems.