Bücher veröffentlicht von Springer Verlag, Singapore

This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.

This book proposes a new interdisciplinary understanding of urban design in China based on a study of the transformative effects of socio-spatial design and planning on communities and their governance. This is framed by an examination of the social projects, spaces, and realities that have shaped three contexts critical to the understanding of urban design problems in China: the histories of ¿collective forms¿ and ¿collective spaces¿, such as that of the urban danwei (work-unit), which inform current community building and planning; socio-spatial changes in urban and rural development; and disparate practices of ¿spatialised governmentality¿. These contexts and an attendant transformation from planning to design and from government to governance, define the current urban design challenges found in the dominant urban xiaoqu (small district) and shequ (community) development model. Examining the histories, transformations, and practices that have shaped socio-spatial epistemologies and experiences in China ¿ including a specific sense of community and place that is rather based on a concrete ¿collective¿ than abstract ¿public¿ space and underpinned by socialised governance ¿ this book brings together a diverse range of observations, thoughts, analyses, and projects by urban researchers and practitioners. Thereby discussing emerging interdisciplinary urban design practices in China, this book offers a valuable resource for all academics, practitioners, and stakeholders with an interest in socio-spatial design and development.

This book presents an innovative systems approach towards the idea of a smarter world, with advanced and sustainable social infrastructures, facilities and services. It develops a novel systems approach for society-wide systems where interdependent systems encompassing transportation, energy, communication, water, sewerage, logistics, education, disaster prevention, medical care and welfare are integrated to form a ¿System of Systems¿ (SoS). Written by leading system scientists and technology creators, it introduces state-of-the-art concepts of and methodologies for systems approaches towards SoS as well as their practical applications, discussing the planning, design and management challenges in their implementation and the potential impact on societies and the environment. The volume will be of interest to systems engineers, system integrators, and researchers in related engineering fields, as well as government policymakers.

This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes¿ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.

This volume offers detailed information on the behaviour of various water pollutants, and on the principles and concepts of groundwater flow and transport. It will help readers to understand and execute the planning, supervision, and review of solute transport and groundwater modeling projects. The book also discusses the role and fate of elements that have been identified as major contaminants in surface and subsurface waters, and their adverse effects on ecology and human health. The book explores this theme throughout four sections ¿ a. Understanding Soil-Water Systems, b. Fate and Transport of Pollutants, c. Physico-Chemical Treatment of Wastewater and d. Microbial Techniques Used to Decontaminate Soil-Water Systems. Introducing readers to a range of recent advances concerning the fundamentals of subsurface water treatment, it offers a valuable guide for teachers, researchers, policymakers, and undergraduate and graduate students of hydrology, environmental microbiology, biotechnology and the environmental sciences. It also provides field engineers and industrial practitioners with essential support in the effective remediation and management of polluted sites.

This informative book discusses the various spectroscopic techniques applied in the analysis of food and beverages. The respective chapters cover techniques such as Laser-Induced Breakdown Spectroscopy (LIBS), FTIR spectroscopy, Electron Spin Resonance (ESR) spectroscopy and Thermoluminescence. The book also presents artificial intelligence applications that can be used to enhance the spectral data analysis experience in food safety and quality analysis. Given its scope, the book will appeal to novice researchers and students in the area of food science. It offers an equally exciting read for food scientists and engineers working in the food industry.

This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies.

This book reviews the application of Nanobiotechnology in the development of Nanomedicine, while also discussing the latest trends and challenges in the clinical translation of Nanomedicine. Nanomedicine refers to the application of Nanotechnology to medicine and holds tremendous potential for achieving improved efficiency, bioavailability, dose response, personalized medicine and enhanced safety as compared to conventional medicines.The book first introduces readers to the basic concepts of Nanomedicine, and to technological advances in and applications of Nanotechnology in treatment, diagnosis, monitoring, and drug delivery. In turn, it reviews the current status of multi-functionalization strategies for using Nanoparticles in the targeted delivery of therapeutic agents. The book¿s third and final section focuses on the regulatory and safety challenges posed by Nanomedicine, including industry and regulatory agencies¿ efforts to address them.

The First Edition of the book is a collection of articles, all by the author, on the Indian mathematical genius Srinivasa Ramanujan as well as on some of the greatest mathematicians in history whose life and works have things in common with Ramanujan. It presents a unique comparative study of Ramanujan¿s spectacular discoveries and remarkable life with the monumental contributions of various mathematical luminaries, some of whom, like Ramanujan, overcame great difficulties in life. Also, among the articles are reviews of three important books on Ramanujan¿s mathematics and life. In addition, some aspects of Ramanujan¿s contributions, such as his remarkable formulae for the number pi, his path-breaking work in the theory of partitions, and his fundamental observations on quadratic forms, are discussed. Finally, the book describes various current efforts to ensure that the legacy of Ramanujan will be preserved and continue to thrive in the future.This Second Edition is an expanded version of the first with six more articles by the author. Of note is the inclusion of a detailed review of the movie The Man Who Knew Infinity, a description of the fundamental work of the SASTRA Ramanujan Prize Winners, and an account of the Royal Society Conference to honour Ramanujan¿s legacy on the centenary of his election as FRS.

This volume comprises select papers presented during the Indian Geotechnical Conference 2018. This volume focuses on discussing the many challenges encountered in geoenvironmental engineering. The book covers sustainability aspects related to geotechnical engineering, problematic soils and ground improvement, use of geosynthetics and concepts of soil dynamics. The contents of this book will be useful to researchers and professionals working in geo-environmental engineering and to policy makers interested in understanding geotechnical concerns related to sustainable development.