Bücher der Reihe Advances in Biochemical Engineering/Biotechnology

Although its roots were developed from other disciplines such as agronomy, agricultural engineering, chemical engineering, forestry, horticulture, hydroge ology, and microbiology, this set of technologies has grown substantially on its own in understanding of and application in the environmental clean up indus try around the world.

Anaerobic digestion is a major field for the treatment of waste and wastewater. In addition, the applications for treatment of waste and wastewaters are presented along with the latest knowledge on process control and regulation of anaerobic bioprocesses.

Systems Metabolic Engineering: The Creation of Microbial Cell Factories by Rational Metabolic Design and Evolution, by Chikara Furusawa, Takaaki Horinouchi, Takashi Hirasawa, Hiroshi Shimizu Impacts of Quorum Sensing on Microbial Metabolism and Human Health, by Yang-Chun Yong, Jian-Jiang Zhong CHO Glycosylation Mutants as Potential Host Cells to Produce Therapeutic Proteins with Enhanced Efficacy, by Peiqing Zhang, Kah Fai Chan, Ryan Haryadi, Muriel Bardor, Zhiwei Song Cell-Free Biosystems for Biomanufacturing, by Chun You, Y.-H. Percival Zhang Lipid Bilayer Membrane Arrays: Fabrication and Applications, by Xiaojun Han, Guodong Qi, Xingtao Xu, Lei Wang RNA Aptamers: A Review of Recent Trends and Applications, by Kyung-Nam Kang, Yoon-Sik Lee

With contributions by numerous experts

Light Microscopic Analysis of Mitochondrial Heterogeneity in Cell Populations and Within Single Cells, by S. Neumann* Advanced Microscopy of Microbial Cells, by J. Yasuda* Measuring the Mechanical Properties of Single Microbial Cells, by C.

With contributions by numerous experts

With contributions by numerous experts

This resource examines trends in modern biotechnology, covering all aspects of this interdisciplinary field.

Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity.

This review series covers trends in modern biotechnology, including all aspects of this interdisciplinary technology, requiring knowledge, methods, and expertise from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.

This book review series presents current trends in modern biotechnology. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.

A study of thermal biosensors, bioactivity and bioaffinity. It is the 64th volume in a series covering actual trends in modern biology.

1 R.M. Raab, K. Tyo, G. Stephanopoulos: Metabolic Engineering.- 2 J. Maury, M.A. Asadollahi, K. Möller, A. Clark, J. Nielsen: Microbial Isoprenoid Production: An Example of Green Chemistry Through Metabolic Engineering.- 3 J.-J. Zhong, C.-J. Yue: Plant Cells: Secondary Metabolite Heterogeneity and its Manipulation.- 4 S. Arnold, M. Siemann-Herzberg, J. Schmid, M. Reuss: Model-Based Inference of Gene Expression Dynamics from Sequence Information.- 5 U.T. Bornscheuer: Trends and Challenges in Enzyme Technology.-

Ranging from evolving nanoanalytical techniques to advances in the material sciences and artificial antibodies and finally continuous large scale separations of the most fragile biologicals, this book should provide interesting reading material for students and practitioners from various fields.

Although there was limited knowledge about the cell's molecular mechanisms, which are the basis for the formation of the desired products, products from fermentation and extraction of biological matrices were a success right from the start.

With contributions by numerous experts

Prospective Isolation and Characterization of Human Bone Marrow-Derived MSCs, by A. Harichandan, K. Sivasubramaniyan, H.-J. BühringUrine as a Source of Stem Cells, by Christina Benda, Ting Zhou, Xianming Wang, Weihua Tian, Johannes Grillari, Hung-Fat Tse, Regina Grillari-Voglauer, Duanqing Pei, Miguel A. Esteban Expansion of Mesenchymal Stem/Stromal Cells under Xenogenic-Free Culture Conditions, by Sven Kinzebach, Karen Bieback Adipose-Derived Mesenchymal Stem Cells: Biology and Potential Applications, by Danielle Minteer, Kacey G Marra, J Peter Rubin Potential for Osteogenic and Chondrogenic Differentiation of MSC, by Antonina Lavrentieva, Tim Hatlapatka, Anne Neumann, Birgit Weyand, Cornelia Kasper Potential for Neural Differentiation of Mesenchymal Stem Cells, by Letizia Ferroni, Chiara Gardin, Ilaria Tocco, Roberta Epis, Alessandro Casadei, Vincenzo Vindigni, Giuseppe Mucci, Barbara Zavan Migratory Properties of Mesenchymal Stem Cells, by Thomas Dittmar, Frank EntschladenDissecting Paracrine Effectors for Mesenchymal Stem Cells, by Stefania Bruno, Federica Collino, Ciro Tetta, Giovanni Camussi Proteomics Approaches in the Identification of Molecular Signatures of Mesenchymal Stem Cells, by Yin Xiao, Jiezhong ChenDoes the Adult Stroma Contain Stem Cells?, by Richard Schäfer

Integration in Bioanalysis: Technologies for Point-of-Care Testing, by Frank F. Bier, Soeren Schumacher Future of Medicine: Models in Predictive Diagnostics and Personalized Medicine, by Babette Regierer, Valeria Zazzu, Ralf Sudbrak, Alexander Kühn and Hans Lehrach A Highly Versatile Microscope Imaging Technology Platform for the Multiplex Real-Time Detection of Biomolecules and Autoimmune Antibodies, by Stefan Rödiger, Peter Schierack, Alexander Böhm, Jörg Nitschke, Ingo Berger, Ulrike Frömmel, Carsten Schmidt, Mirko Ruhland, Ingolf Schimke, Dirk Roggenbuck, Werner Lehmann, Christian Schröder Platform Technologies for Molecular Diagnostics near the Patient¿s Bedside, by Soeren Schumacher, Christine Lüdecke, Eva Ehrentreich-Förster, Frank F. Bier Microfluidic Technology for Molecular Diagnostics, by Tom Robinson, Petra S. Dittrich Biosensors for Diagnostic Applications, by Friederike J. Gruhl, Bastian E. Rapp, Kerstin Länge Planar Protein Arrays in Microtiter Plates: Development of a New Format Towards Accurate, Automation-Friendly and Affordable (A3) Diagnostics, by Holger Eickhoff, Arif Malik

Engineered MSCs from Patient-Specific iPS Cells, by Irina Eberle, Mohsen Moslem, Reinhard Henschler, Tobias Cantz Fate of Intravenously Injected Mesenchymal Stem Cells and Significance for Clinical Application, by Beate Wagner, Reinhard Henschler The Implications of Stem Cell Applications for Diseases of the Respiratory System, by Mei Ling Lim, Philipp Jungebluth, Paolo Macchiarini Potential of Mesenchymal Stem Cell Applications in Plastic and Reconstructive Surgery, by Birgit Weyand, Peter M. Vogt General Principles for the Regeneration of Bone and Cartilage, by Michael Jagodzinski, C. Haasper Adult Mesenchymal Stem Cells Explored in the Dental Field, by K. M. Fawzy El-Sayed, C. Dörfer, F. Fändrich, F. Gieseler, M. H. Moustafa, H. Ungefroren Mesenchymal Stem Cell Therapy and Lung Diseases, by Khondoker M. Akram, Sohel Samad, Monica Spiteri, Nicholas R. Forsyth Mesenchymal Stem Cells as Cellular Immunotherapeutics in Allogeneic Hematopoietic Stem Cell Transplantation, by Claudia Papewalis, Daniela Topolar, Barbara Götz, Stefan Schönberger, Dagmar Dilloo New Cell-Based Therapy Paradigm: Induction of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells into Pro-Inflammatory MSC1 and Anti-inflammatory MSC2 Phenotypes, by Aline M. Betancourt Interactions Between Mesenchymal Stem Cells and Dendritic Cells, by Grazia Maria Spaggiari, Lorenzo Moretta MSC and Tumors: Homing, Differentiation, and Secretion Influence Therapeutic Potential, by Naomi D¿souza, Jorge Sans Burns, Giulia Grisendi, Olivia Candini, Elena Veronesi, Serena Piccinno, Edwin M. Horwitz, Paolo Paolucci, Pierfranco Conte, Massimo Dominici Sources of Mesenchymal Stem Cells: Current and Future Clinical Use, by Michela Pozzobon, Martina Piccoli, Paolo De Coppi Role of the EU Framework in Regulation of Stem Cell-Based Products, by Giovanni Migliaccio, Cristina Pintus