Bücher der Reihe Advances in Experimental Medicine and Biology

Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics.

Topics in Part III include the role of sumoylation in developmental abnormalities (craniofacial and cardiovascular), diabetes, neurodegenerative diseases, cancer, and infections with viruses and bacteria.Each of the corresponding chapter authors is an active researcher who has made significant contributions to understanding sumoylation.

This text examines in detail mathematical and physical modeling, computational methods and systems for obtaining and analyzing biological structures, using pioneering research cases as examples.

This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as "Anticancer Genes", are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application.Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells.With contributions from experts worldwide, Anticancer Genes is an essential guide to this dynamic topic for researchers and students in cancer research, molecular medicine, pharmacology and toxicology and genetics as well as clinicians and clinical researchers interested in the therapeutic potential of this exciting new field.

This book is meant to provide the most current knowledge regarding the mechanisms of action of A20, if its versatile functions and their validation in animal models of human disease and its promise as a diagnostic biomarker and therapeutic target.

This book contains the refereed contributions from the 41st annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. Traditionally, ISOTT conferences are a place, where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The papers in this volume summarize some of the outstanding contributions from the 41st annual meeting. Special features in this volume include invited presentations from senior members of ISOTT for the theme ¿the wisdom of ISOTT¿ in which founders, past presidents and prize winners from previous meetings provided both cutting edge new knowledge and integratedoverviews of critical aspects of the field. The presentations and manuscripts also include those provided by the special opportunity provided by having part of the ISOTT meeting overlap with the EPR-2013 meeting where both focused on preclinical and clinical measurements of oxygen, with a particular emphasis on cancer.Chapters 22, 24, 25 and 26 are open access under a CC BY 4.0 license via link.springer.com.

"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis.

Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders.

This volume takes two approaches to this topic - (1) illustrating the general principles outlined above through a series of different stem cell examples - embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

This book is the first comprehensive review of drebrin, which plays pivotal roles in various cellular events, via forming unique actin cytoskeletons, including synapse formation and in synaptic function.

Cardiovascular immunology is a newly emerging research area, investigating the crosstalk between the cardiovascular and the immune system. This crosstalk is evident through (1) crucial immunological capacities and functions of cardiovascular cell types, including cardiomyocytes, fibroblasts, endothelial cells, pericytes and cardiac resident macrophages, (2) the impact of aberrant immune function on the development of cardiovascular disease such as atherosclerosis, direct and indirect immune-mediated heart disease and vasculitis, and (3) the crucial role of the immune system in cardiac repair and regeneration. The Immunology of Cardiovascular Homeostasis and Pathology covers all these aspects of cardiovascular immunology, starting with homeostatic immunological functions of traditional cardiovascular cell types, and moving then to the role of the immune system in cardiovascular pathology and to recent research into targeting the immune system to boost cardiac healing and regeneration.

Hereditary tyrosinemia type 1 (HT1), the most severe inborn error of the tyrosine degradation pathway, is due to a deficiency in fumarylacetoacetate hydrolase (FAH).

This book describes the newest discoveries on calcium signaling happening at the cellular and intracellular membranes, often exerted in so called microdomains. Calcium entry and release, its interaction with proteins and resulting events on proteins and organelles are comprehensively depicted by leading experts in the field. Knowledge about details of these highly dynamic processes rapidly increased in recent years, the book therefore provides a timely summary on the processes of calcium signaling and related membrane dynamics; it is aimed at students and researchers in biochemistry and cell biology.

This book is about the roles and importance of Ultraviolet (UV) light from sun and from man-made UV lamps in our daily life, on health and diseases, also its application in sterilization and treatment. The key words are: reactive oxygen species, DNA damage, UV mutagenicity, skin cancers, polymorphous light eruption, Xeroderma pigmentosum, vitiligo, psoriasis, rheumatoid arthritis, diabetes mellitus, metabolic syndromes, cardiovascular diseases, dermatology, photobiology, photodermatosis, vitamin D synthesis, vitamin D efficiency, water sterilization, blood sterilization, phototherapies, skin tanning and UV dosimeter.The book starts with introduction to UV light and the history of development of UV lamps and its applications. It then moves to describing the interaction of this light with biological components and the production of reactive oxygen species, their roles in cell signaling, cellular defense from foreign invaders, in mutagenesis leading to skin diseases including vitiligo, polymorphous light eruption and various forms of skin cancer. Then it presents the synthesis and importance of UV light and diseases, induced due to the deficiency of vitamin D. Roles of UV light in sterilization, disinfection, phototherapies are depicted in the next part and finally use and abuse of UV light in tanning salon and the availability and importance of use of UV dosimeter are highlighted.The three main focuses of this book are: - Damage to biological systems by UV light leading to certain skin diseases; most importantly skin cancers. - Importance of UV light in the in vivo synthesis of vitamin D when human bodies are exposed to it. - Diseases caused due to the deficiency of vitamin D and the use of UV lamps in phototherapy and sterilization processes.The editor has considerable experience in publishing medical books and has used it critically selecting the matters which will attract the readers from many areas of medical and non-medical fields.It is hoped that the materials presented in this book will give great benefit and will stimulate both novice and expert researchers in the field. The book gives excellent overviews of the current status of research and pointers to the future research achievements. Clinicians, medical general practitioners, technicians and staff working in UV related industries and especially those working in tanning salon should benefit from the information presented in safe handling of this light.

The book provides an intensive overview on exercise for cardiovascular disease prevention and treatment, from basic research to clinical practice.

The book provides an intensive overview on exercise for cardiovascular disease prevention and treatment, from basic research to clinical practice.

The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions.

This volume is the most recent installment of the Progress in Motor Control series. The Progress in Motor Control IXI meeting, and consequently this volume, provide a broad perspective on the latest research on motor control in humans and other species.

Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies.

After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes.

The recently acquired knowledge on the pivotal role played by biofilm-growing microorganisms in healthcare-related infections has given a new dynamic to detection, prevention and treatment of these infections in patients admitted to both acute care hospitals and long-term care facilities.

In the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. This proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013.

This book's aim is to increase the awareness of a great variety of posttranslational modifications in the male and female reproductive system. Chapters are also devoted to protein ubiquitination, the regulation of sperm function during fertilization in mammals and tubulin modifications in gametes and embryos.

Reproductive biology is more than the development of techniques for helping with too little or too much breeding. reproductive fitness and (3) it looks forward and presents realistic assessments of how effective some of the more recently developed techniques in reproductive technology might be at combating extinctions.

The 2nd World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2016), focuses on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and provides an international forum for the latest scientific discoveries, medical practices and care initiatives.

The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized.

This book provides everything from basic knowledge to the recent understandings of avian reproductive physiology, covering many unique aspects.