Bücher der Reihe Progress in the Chemistry of Organic Natural Products

The present volume is the third in a trilogy that documents naturally occurring organohalogen compounds, bringing the total number ¿ from fewer than 25 in 1968 ¿ to approximately 8,000 compounds to date. Nearly all of these natural products contain chlorine or bromine, with a few containing iodine and, fewer still, fluorine. Produced by ubiquitous marine (algae, sponges, corals, bryozoa, nudibranchs, fungi, bacteria) and terrestrial organisms (plants, fungi, bacteria, insects, higher animals) and universal abiotic processes (volcanos, forest fires, geothermal events), organohalogens pervade the global ecosystem. Newly identified extraterrestrial sources are also documented. In addition to chemical structures, biological activity, biohalogenation, biodegradation, natural function, and future outlook are presented.

The book covers the totality of bilirubin (and heme from which bilirubin is derived biogenetically) the structural relationship of bilirubin to its solution properties and metabolism and to phototherapy for the jaundiced newborn - a common medical procedure used nowadays for lowering serum bilirubin, which is neurotoxic.

A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type.

The biological activity of mycotoxins ranges from weak and/or sometimes positive effects, such as antibacterial activity (see penicillin derivatives derived from Penicillium strains) to strong mutagenic (e. Sections are arranged according to mycotoxin classes (e. aflatoxins) and/or structural classes (e.

Includes the three reviews that cover the advances in the chemistry and biology of withanolides, and review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis.

This book provides an illustrative overview of successful and widely used applications of organocatalysis in the field of natural product synthesis. The main focus is on organocatalytic key-steps for each (multi-step) synthesis described.

For some 50 years, Professor Asakawa and his group have focused their research on the chemical constituents of bryophytes and have found that these plants contain large numbers of secondary metabolites, such as terpenoids, acetogenins, and aromatic compounds representative of many new skeletons, which exhibit interesting biological activities.