Bücher veröffentlicht von Humana Press Inc.

The growth of the field of eating disorder research has led to a vast array of empirical articles, and the development of new animal models that can be used to study these disorders continues to stimulate new research.

As ever more petabytes of information are added to biological databases such as that for the human genome, this new volume in the Methods in Molecular Biology series explains how to convert the deluge of fresh data into new knowledge and biological insight.

The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.

This volume in the Methods in Pharmacology and Toxicology(TM) series covers modeling methodologies involving disorders of the cardiovascular system, the brain, skin and metabolic system, as well as colitis, cancer, thermosensation and musculoskeletal disorders.

Therapeutic applications within regenerative biomedicine has gained tremendous interest from a growing, multidisciplinary community of investigators in recent years, driven by the hope of finding cures for several diseases.

This volume covers an array of topics from the employment of the chick CAM model using fluorescent proteins and other fluorescent probes, to intravital fluorescent imaging, as well as 3-dimensional imaging, and design instructions on how to create new and improved far-red and infrared fluorescent proteins, to name a few.

However, upon further reflection we accepted a place for a book that could combine our career this mandate as a blessing in disguise, allowing the experiences of trying to discern what is known (and reader to focus on differences in morphology, rather knowable) with the perennially proposed question, than tincture, as a guide to correct diagnosis.

This volume provides readers with an introduction to all the methods and major approaches now being used to study the structural and functional development of the brain.

Thee readily reproducible proteomic methods range from general to specific techniques, and include methods for data analysis, posttranslational modification, and its variants and isoforms.

The authors' understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity situations (space flight), and hastening the healing of fractures, osteotomies, and antrodeses.

Takes stock of the work that has been accomplished with proteasome inhibitors in cancer, and examines various therapeutic possibilities. This title covers topics ranging from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of clinical trials underway.

The author presents in an easily digestible form a dictionary of antibody probes, summarizing for each antibody the targeted antigen and its cellular function, its diagnostic utility, and, when available, its sensitivities and specificities for identifying various neoplasms.

A comprehensive and critical review of the latest scientific advances in our understanding of the molecular genetics and biology of CLL and their application to the best management of CLL.

Leading physicians from a variety of medical specialties summarize their clinical experiences in treating pituitary adenomas in United States and the United Kingdom. Using simple language to describe their approaches, the authors describe the latest treatments for prolactinoma, acromegaly, Cushing's disease, and nonfunctioning pituitary tumors, and the latest surgical techniques. To round out the clinician's understanding of the illness, a patient describes the experience of diagnosis, treatment, and follow-up. Comprehensive and accessible, Management of Pituitary Tumors: The Clinician's Practical Guide brings together all the medical fields involved in treating pituitary tumors, both for novices in the specialties that manage these cases, and for pituitary specialists seeking to understand better the contribution of other medical disciplines to the treatment of these tumors.

The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.

Throughout the more than 20 years that have followed the beginnings of capillary electrophoresis (CE), its application to the analysis of proteins and peptides has continued to be reliable, versatile, and productive.

Guidelines for Reports by Autopsy Pathologists is intended to help the autopsy pathologist produce reports that communicate well.

This Handbook reviews neuroprotection based on contemporary understanding of the molecular basis of neurological disorders. Cutting-edge and innovative, the book documents neuroprotective effects of established drugs, as well as new drugs in development.

Dopamine, a catecholamine transmitter, plays a number of vital physiological roles in the brain and body, and, in recent years, studies on the role of dopamine in disease have opened new avenues of research and discovery.

Cell senescence is the process whereby cells permanently lose the possibility to proliferate without undergoing cell death, and occurs in a plethora of distinct model organisms.

The receptor-associated JAK protein kinases and their substrates, the STAT transcriptional activators, transmit signals following cytokine and growth factor binding to receptors expressed on the cell surface, to result in specific transcriptional and cellular responses.

This Neuromethods series book reviews methods for generating lesions and for stimulating and inhibiting neural pathways, covering new techniques such as optogenetics and the use of the in situ perfused preparation and reassessing well-known approaches.

This Methods in Molecular Biology(TM) book reviews common techniques for studying calcium binding proteins, underlining the diagnostic and clinical importance of this family of proteins. Offers materials lists, protocols, troubleshooting advice and more.

This Methods in Molecular Biology(TM) book covers topics such as how to image the structure of plant ovules and embryos, tools for establishing cell lineages, methods for studying the totipotency of plant cells, fluorescence-activated cell sorting and more.

This Methods in Molecular Biology(TM) volume collects reliable protocols covering a wide range of techniques and experimental models, specific molecular assays and disease models, and provides overviews of diagnostic and research topics in molecular dermatology.

Antigen processing is a biological process that prepares antigens for the presentation to special cells in the immune system called T lymphocytes.

Carotenoids and Human Health provides an introduction to food sources and metabolism. Comprehensive and easy to use, Carotenoids and Human Health is a very useful resource for nutritionists, registered dieticians, medical students, and graduate students.

This Methods in Molecular Biology(TM) book covers creation and monitoring of transgenic cotton, including techniques for detecting foreign gene copy and expression, methods for monitoring the potential environmental impact of transgenic cotton and more.

This book in the Neuromethods series examines a range of experimental models for research on spinal cord injury, shows how they have contributed to our current state of knowledge, and describes their advantages in the further advancement of spinal cord repair.