Bücher veröffentlicht von Springer US

In this book the author sets out to answer two important questions: 1. Which numerical methods may be combined together? 2. How can different numerical methods be matched together? In doing so the author presents a number of useful combinations, for instance, the combination of various FEMs, the combinations of FEM-FDM, REM-FEM, RGM-FDM, etc. The combined methods have many advantages over single methods: high accuracy of solutions, less CPU time, less computer storage, easy coupling with singularities as well as the complicated boundary conditions. Since coupling techniques are essential to combinations, various matching strategies among different methods are carefully discussed. The author provides the matching rules so that optimal convergence, even superconvergence, and optimal stability can be achieved, and also warns of the matching pitfalls to avoid. Audience: The book is intended for both mathematicians and engineers and may be used as text for advanced students.

It has been exciting to witness the discovery that most peptic ulcers are caused by a bacterium that is relatively easy to eradicate. Most doctors now aim to give their patients the benefits of this unexpected breakthrough, but the new knowledge raises many questions. One is precisely which groups of patients to treat. We should restrict ourselves to the infected, but which of the many tests should we use to identify them? Having decided to treat, which of the plethora of regimens should we use? These questions have been particularly difficult to address at a time when knowledge and c1inical techniques are still developing rapidly. This book aims to present the current scene in an objective and digestible form, so that c1inicians can choose strategies which suit their local needs. The relative merits of the various c1inical ap- proaches are discussed, together with some scientifie background to prepare the reader for future developments. The book is primarily aimed at practising c1inieians but should be equally useful for stu- dents preparing for examinations. It will also provide a source of reference to workers in the pharmaceutical industry, journalism or marketing who need to get 'up-to-speed' in this area.

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . , ** , . . , . . I . . . I . . . . . I . . . . . I . . . . . . . . . . . . . . . . . . . . . . . t . . . . . . . . . I . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I . . . . . . . . t , , . . "e; . . . . . . . . . . . . Common Conditions in Gynaecology: A problem-solving approach is not meant to be a fully comprehensive gynrecological text although the majority of conditions, particularly those occurring commonly, are well covered. The emphasis of this book is in dealing with problems rather than learning pathologies. This book advocates a patient-centred ap- proach to the discussion, diagnosis and management of conditions presenting as gynrecological problems. The emphasis throughout is on the acquiring of clinical skill rather than the storage of facts. The authors acknowledge of course that some factual information is neces- sary, but only to provide the basis upon which to build the clinical and communicative skills that are now well recognized as the major goals of a medical education. No book can ever replace the experience gained in the clinic and at the bedside, this book aims to complement and indeed foster a true clinical learning mode. We hope that all who have an interest in caring for and learning more about women with gynrecological problems might find this book of value. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . , . . , . . . . . . . Doctor-patient communication and 1 the gyn~cological history . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . , . . . . . . . . . . . . . . . . . . . , . . . . . . . . . . . . . . . . . , . . . . . . . . . . . . . . . . . . . . . . . . , . . . , . . . . . . . . . . . . . Kevin Browne and Clare Davenport 1.

This book by Kaplan and Vekhter brings together the molecular world of the chemist with the condensed matter world of the physicist. Prior to the collapse of the Soviet Union, chemists in the West devoted lit­ to relationships between molecular electronic structure and tle attention solid-state vibronic phenomena. Treating quantum mechanical problems wherein the adiabatic Born-Oppenheimer approximation fails was done by "brute force. " With bigger and better computers available in the West, molecular orbital calculations were done on observed and conceived static structures with little concern for any cooperativity of vibrational behavior that might connect these states. While it had long been understood in the West that situations do occur in which different static structures are found for molecules that have identical or nearly identical electronic structures, little attention had been paid to understanding the vibrational states that could connect such structures. It was easier to calculate the electronic structure observed with several possible distortions than to focus on ways to couple electronic and vibrational behavior. In the former Soviet Union, computational power was not as acces­ sible as in the West. Much greater attention, therefore, was devoted to conserving computational time by considering fundamental ways to han­ dle the vibrational connectivity between degenerate or nearly degenerate electronic states.

Due to the worldwide epidemic of acquired immunodeficiency syndrome (AIDS), the past ten years have witnessed a flurry of activity in the chemotherapy of viral diseases. Unprecedented scientific efforts have been made by scientists and clinicians to combat infections of human immunodeficiency virus (HIY), the causative agent. Looking back over the past ten years, we have made remarkable progress toward the treatment of the viral disease: isolation of HIV only two years after the identification of the disease, plus major strides in the areas of the molecular biology and virology of the retrovirus, etc. More remarkably, the discovery of the chemotherapeutic agent AZT (Retrovir) was made within two years after the isolation and identification of the virus, followed by unprecedented drug development efforts to culminate in the FDA approval of AZT in twenty-three months, which was a record-breaking time for approval of any drug for a major disease. The last six to seven years have particularly been an exciting and productive period for nucleoside chemists. Since the activity of AZI' was established in 1985, nucleoside chemists have had golden opportunities to discover additional anti-HIV nucleosipes, which are hoped to be less toxic and more effective than AZT, and the opportunity continues. As we all are aware, AZT possesses extremely potent anti-HIY activity, and no other nucleoside or non­ nucleoside has surpassed the potency of AZT in vitro.

During the past fifty years, thousands of natural products have been isolated from plants, fungi, and bacteria. Apart from intense searches by pharmaceutical companies for medicinals and the concentrated effort mounted by the National Cancer Institute, many of these have not been tested in biological systems. The major reasons for this appear to be, at least, twofold. First, individual researchers looking for biologically active natural products will often isolate only small amounts of material sufficient to determine a structure and calculate the specific activity for their particular bioassay systems: insufficient funds preclude re-isolating the compound unless industrial potential is foreseen. Second, the difficulty with which original structures were proved prior to 1972. This required the isolation of relatively large quantities of a natural product and there followed extensive degradation, elemental analyses of the parent and its fragments, then synthesis, piece by piece, of the molecule. All this took time and energy. No wonder that when the structure was proved the chemist was enervated. And coupled to this was the fact that many chemists were not trained to test their materials in biological systems. In contrast, today a natural product can be isolated, its mass and molecular formula determined and, if there is some serendipity, crystals may be obtained for single crystal x-ray analysis. If conditions are near perfect, it is possible to isolate and identify a novel compound in a month.

Non-Functional Requirements in Software Engineering presents a systematic and pragmatic approach to `building quality into' software systems. Systems must exhibit software quality attributes, such as accuracy, performance, security and modifiability. However, such non-functional requirements (NFRs) are difficult to address in many projects, even though there are many techniques to meet functional requirements in order to provide desired functionality. This is particularly true since the NFRs for each system typically interact with each other, have a broad impact on the system and may be subjective. To enable developers to systematically deal with a system's diverse NFRs, this book presents the NFR Framework. Structured graphical facilities are offered for stating NFRs and managing them by refining and inter-relating NFRs, justifying decisions, and determining their impact. Since NFRs might not be absolutely achieved, they may simply be satisfied sufficiently (`satisficed'). To reflect this, NFRs are represented as `softgoals', whose interdependencies, such as tradeoffs and synergy, are captured in graphs. The impact of decisions is qualitatively propagated through the graph to determine how well a chosen target system satisfices its NFRs. Throughout development, developers direct the process, using their expertise while being aided by catalogues of knowledge about NFRs, development techniques and tradeoffs, which can all be explored, reused and customized. Non-Functional Requirements in Software Engineering demonstrates the applicability of the NFR Framework to a variety of NFRs, domains, system characteristics and application areas. This will help readers apply the Framework to NFRs and domains of particular interest to them. Detailed treatments of particular NFRs - accuracy, security and performance requirements - along with treatments of NFRs for information systems are presented as specializations of the NFR Framework. Case studies of NFRs for a variety of information systems include credit card and administrative systems. The use of the Framework for particular application areas is illustrated for software architecture as well as enterprise modelling. Feedback from domain experts in industry and government provides an initial evaluation of the Framework and some case studies. Drawing on research results from several theses and refereed papers, this book's presentation, terminology and graphical notation have been integrated and illustrated with many figures. Non-Functional Requirements in Software Engineering is an excellent resource for software engineering practitioners, researchers and students.

Algorithms for VLSI Physical Design Automation is a core reference text for graduate students and CAD professionals. It provides a comprehensive treatment of the principles and algorithms of VLSI physical design. Algorithms for VLSI Physical Design Automation presents the concepts and algorithms in an intuitive manner. Each chapter contains 3-4 algorithms that are discussed in detail. Additional algorithms are presented in a somewhat shorter format. References to advanced algorithms are presented at the end of each chapter. Algorithms for VLSI Physical Design Automation covers all aspects of physical design. The first three chapters provide the background material while the subsequent chapters focus on each phase of the physical design cycle. In addition, newer topics like physical design automation of FPGAs and MCMs have been included. The author provides an extensive bibliography which is useful for finding advanced material on a topic. Algorithms for VLSI Physical Design Automation is an invaluable reference for professionals in layout, design automation and physical design.

Chromosome biology has been brought to a golden age by phenomenal advanced in molecular genetics and techniques. This is true in the plant arena, and it is becoming increasingly true in animal studies, where chromosomes are more difficult to work with. With advanced knowledge of transformation, scientists can tell exactly where a new element enters a chromosome. Conversely, molecular biologists can make large mistakes if they do not understand the behavior of chromosomes. Written by internationally recognized experts in the field, this book is the most authoritative work on the subject to date. Students of genetics, crop science and plant breeding, entomology, animal science, and related fields will benefit from this comprehensive and practical textbook.

The primary audience for this book are advanced undergraduate students and graduate students. Computer architecture, as it happened in other fields such as electronics, evolved from the small to the large, that is, it left the realm of low-level hardware constructs, and gained new dimensions, as distributed systems became the keyword for system implementation. As such, the system architect, today, assembles pieces of hardware that are at least as large as a computer or a network router or a LAN hub, and assigns pieces of software that are self-contained, such as client or server programs, Java applets or pro- tocol modules, to those hardware components. The freedom she/he now has, is tremendously challenging. The problems alas, have increased too. What was before mastered and tested carefully before a fully-fledged mainframe or a closely-coupled computer cluster came out on the market, is today left to the responsibility of computer engineers and scientists invested in the role of system architects, who fulfil this role on behalf of software vendors and in- tegrators, add-value system developers, R&D institutes, and final users. As system complexity, size and diversity grow, so increases the probability of in- consistency, unreliability, non responsiveness and insecurity, not to mention the management overhead. What System Architects Need to Know The insight such an architect must have includes but goes well beyond, the functional properties of distributed systems.

Plasma processing of semiconductors is an interdisciplinary field requiring knowledge of both plasma physics and chemical engineering. The two authors are experts in each of these fields, and their collaboration results in the merging of these fields with a common terminology. Basic plasma concepts are introduced painlessly to those who have studied undergraduate electromagnetics but have had no previous exposure to plasmas. Unnecessarily detailed derivations are omitted; yet the reader is led to understand in some depth those concepts, such as the structure of sheaths, that are important in the design and operation of plasma processing reactors. Physicists not accustomed to low-temperature plasmas are introduced to chemical kinetics, surface science, and molecular spectroscopy. The material has been condensed to suit a nine-week graduate course, but it is sufficient to bring the reader up to date on current problems such as copper interconnects, low-k and high-k dielectrics, and oxide damage. Students will appreciate the web-style layout with ample color illustrations opposite the text, with ample room for notes.This short book is ideal for new workers in the semiconductor industry who want to be brought up to speed with minimum effort. It is also suitable for Chemical Engineering students studying plasma processing of materials; Engineers, physicists, and technicians entering the semiconductor industry who want a quick overview of the use of plasmas in the industry.

Volcanic eruptions are fascinating manifestations of the Earth's dynamic inte- rior which has been cooling for the past several billion years. The planets of the solar system originated some 4.5 billion years ago from the same gas and dust cloud created by the big bang. Some of the gas collapsed by the gravitational force to form the Sun at the center, while the whirling disk of gas and dust around the Sun subsequently cooled and lumped together to form larger and larger lumps of materials or planetesimals. These planetesimals collided fre- quently and violently and in the process liberated heat that melted the material in them. With time this material gradually cooled and formed the planets of the solar system. During the second half of the twentieth century the theory of plate tectonics of the Earth became established and demonstrated that our planet is covered with six large and many small plates of the lithosphere. These plates move over a highly viscous lower part of the Earth's upper mantle and contain the continental and oceanic crusts. The lower mantle extends below the upper mantle until it meets the core that is more than half the diameter of the entire globe (12,740 km). The inner core consists mostly of iron and its temperature is about 5000 kelvin, whereas the liquid outer core is turbulent, rotates faster than the mantle, consists primarily of iron, and is the source of the Earth's magnetic field.