A Comparison between Islet and Stem Cell Transplantation for T1DM

The incidence of Type 1 Diabetes Mellitus (T1DM) has been increasing rapidly worldwide, while the current standard therapy ¿ exogenous insulin supply ¿ is considered unsustainable and highly associated with poor glycemic control that may lead to a life-threatening condition. On the other hand, cellular-based therapy including either islet cell or stem cell transplantation has been recently developed, making it pertinent to compare the effectiveness between the two alternative treatments. The aim of this systematic review is to compare the safety and effectiveness between islet cell transplantation and stem cell transplantation for future practice change.