Große Auswahl an günstigen Büchern
Schnelle Lieferung per Post und DHL

Disordered Cu Transport Across Brain Barriers Following MN Exposure

Über Disordered Cu Transport Across Brain Barriers Following MN Exposure

Increased Cu levels in blood, saliva and brain are found in Mn-exposed animals and humans; the underlying mechanism is unknown. Dyshomeostasis of Cu in the central nervous system is known to contribute to the pathogeneses of several neurodegenerative diseases. Regulation of cellular Cu homeostasis involves Cu-transporting ATPases (Cu-ATPases), i.e., ATP7A and ATP7b. Both transporters play an important role in removing excess Cu ions from the cytosol. However, the questions as to whether and how Cu-ATPases in the brain barrier systems transport Cu, i.e., toward brain parenchyma, cerebrospinal fluid, or blood, and whether and how Mn exposure affects the transport function of both Cu-ATPases, remained unanswered. This study was designed to characterize the role of Cu-ATPases in regulating Cu transport at the blood-brain and blood-cerebrospinal fluid barriers and to investigate how exposure to Mn may alter the function of ATP7A and ATP7B, thereby contributing to the etiology of Mn-induced Parkinsonian disorder.

Mehr anzeigen
  • Sprache:
  • Englisch
  • ISBN:
  • 9783659529283
  • Einband:
  • Taschenbuch
  • Seitenzahl:
  • 252
  • Veröffentlicht:
  • 22 April 2014
  • Abmessungen:
  • 229x152x14 mm.
  • Gewicht:
  • 372 g.
  Versandkostenfrei
  Versandfertig in 1-2 Wochen.

Beschreibung von Disordered Cu Transport Across Brain Barriers Following MN Exposure

Increased Cu levels in blood, saliva and brain are found in Mn-exposed animals and humans; the underlying mechanism is unknown. Dyshomeostasis of Cu in the central nervous system is known to contribute to the pathogeneses of several neurodegenerative diseases. Regulation of cellular Cu homeostasis involves Cu-transporting ATPases (Cu-ATPases), i.e., ATP7A and ATP7b. Both transporters play an important role in removing excess Cu ions from the cytosol. However, the questions as to whether and how Cu-ATPases in the brain barrier systems transport Cu, i.e., toward brain parenchyma, cerebrospinal fluid, or blood, and whether and how Mn exposure affects the transport function of both Cu-ATPases, remained unanswered. This study was designed to characterize the role of Cu-ATPases in regulating Cu transport at the blood-brain and blood-cerebrospinal fluid barriers and to investigate how exposure to Mn may alter the function of ATP7A and ATP7B, thereby contributing to the etiology of Mn-induced Parkinsonian disorder.

Kund*innenbewertungen von Disordered Cu Transport Across Brain Barriers Following MN Exposure



Ähnliche Bücher finden
Das Buch Disordered Cu Transport Across Brain Barriers Following MN Exposure ist in den folgenden Kategorien erhältlich:

Willkommen bei den Tales Buchfreunden und -freundinnen

Jetzt zum Newsletter anmelden und tolle Angebote und Anregungen für Ihre nächste Lektüre erhalten.