Molecular pathological biology of Coronavirus infection SARS-CoV-2

Coronaviruses are a family of RNA viruses that infect humans and other mammals, birds and amphibians. The virus genome is single-stranded positive RNA, which codes nucleoprotein, membrane protein, envelop protein, spike glycoprotein, polymerase. Coronaviruses are characterized by glycoprotein S, the transmembrane proteins M and E, and nucleoprotein combines with the viral RNA to form a viral ribonucleoprotein complex. Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) membrane protein is a glycosylated structural protein that localizes to the endoplasmic reticulum and Golgi and is essential for the assembly of viral particles.