Naturally Occurring Benzodiazepines, Endozepines, and their Receptors

Understanding and addressing the current opioid crisis requires knowledge of the endogenous opioids (endorphins and enkephalins), but there is now evidence for a benzodiazepine crisis. Are there endogenous benzodiazepine-like substances ¿ and what do they do? How do they affect the anti-anxiety drugs and their adverse effects?