Osteoporosis in Cholelithiasis: Biochemical Markers

Osteoporosis (OP) is the condition in which a low bone mass and altered microarchitecture of the bone leads to increased risk of fracture. The major role cytokines play in bone remodeling is demonstrated by the fact that receptors for the proinflammatory cytokines [IL-1, IL-6, TNF-¿] are present on both osteoclast precursor cells and mature osteoclasts. Thus an elevation in these cytokines in cholelithiatic patients act on their receptors in bone cells and induce bone remodeling.In addition the decreased level of vitamin (D) in choleliyhiatic patients due to malabsorption also leads to osteoporosis by several cascades.this study had evaluated the pro-inflammatory cytokines effects on cholilethiatic patients and the levels of bone formation and bone resorption markers. Also to study the biochemical changes in some parameters[ (IL-1 and IL-6), TNF-¿, highly sensitive C-reactive protein (hs ¿ CRP), Vit.D,parathyroid hormone (PTH),calcium( Ca++), inorganic phosphate, C-terminal telopeptide of type I collagen(CTX), Carboxyterminal propeptide of type I procollagen(PICP), free teststeron and estradiol]. in Cholelithiatic each parameter may play a role in the pathogenesis of gallstones.